Abstract
Purpose :
To assess central corneal thickness (CCT) and its associations in a Russian population.
Methods :
The Ural Eye and Medical Study included 5899 (80.5%) out of 7328 eligible individuals (mean age:59.0±10.7 years;range:40-94 years). As part of an ophthalmological and general examination, CCT was measured by Pentacam HR (Oculus, Germany).
Results :
The study included 5792 (98.2%) participants (mean age:58.8±10.6 years;range:40-94 years) with available bilateral CCT measurements. Mean CCT was 541.7±33.7µm (median:541µm;range:200-779µm). In multivariable analysis, thicker CCT was associated (regression coefficient r:0.43) with younger age (standardized regression coefficient beta:-0.09;non-standardized regression coefficient B:-0.29;95% confidence interval (CI):-0.39,-0.20;P<0.001), male sex (beta:0.05;B:3.10;95%CI:1.18,5.03;P=0.002), urban region of habitation (beta:0.10;B:6.83;95%CI:4.61,9.05;P<0.001), Russian ethnicity (beta:0.04;B:3.48;95%CI:1.04,5.91;P=0.005), higher level of education (beta:0.04;B:0.97;95%CI:0.29,1.66;P=0.006), higher serum bilirubin concentration (beta:0.05;B:0.15;95%CI:0.07,0.23;P<0.001), lower corneal refractive power (beta:-0.09;B:11.92;95%CI:-2.50,-1.35;P<0.001), smaller anterior chamber angle (beta:-0.07;B:-0.38;95%CI:-0.52,-0.24;P<0.001), higher IOP readings (beta:0.38;B:3.47;95%CI:3.21,3.73;P<0.001), and higher rise in IOP readings by medical mydriasis (beta:0.07;B:0.88;95%CI:0.54,1.22;P<0.001). In that model, CCT was not associated with body height (P=0.14), previous cataract surgery (P=0.10), axial length (P=0.18) or prevalence of glaucoma (P=0.11). The mean inter-eye difference in CCT was 8.52±13.9 µm (median:6.0;95CI:8.16,8.88). A higher inter-eye CCT difference was associated with older age (beta:0.08;B:0.11;95%CI:0.07,0.15;P=0.01), lower level of education (beta:-0.04;B:-0.34;95%CI:-0.60,-0.08;P<0.001) and status after cataract surgery (beta:0.04;B:2.92;95%CI:1.02,4.83;P=0.003).
Conclusions :
In this typical, ethnically mixed,population from Russia with an age of 40+ years, mean CCT (541.7±33.7µm) was associated with parameters such as younger age, male sex, Russian ethnicity, and higher educational level. These associations may be taken into account when the dependence of IOP readings on CCT are considered. Glaucoma prevalence was unrelated to CCT.
This is a 2021 ARVO Annual Meeting abstract.