June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Comparative Assessment of Long-Term Longitudinal Multi-Layer Retinal Dynamics in Non-neovascular Age-Related Macular Degeneration in Eyes Progressing to Subfoveal Geographic Atrophy and Eyes without Progression
Leina Lunasco; Joseph Roy Abraham; Kubra Sarici; Duriye Damla Sevgi; Annapurna Hanumanthu; Hasan Cetin; Ming Hu; Sunil K. Srivastava; Jamie Reese; Justis P Ehlers
Author Affiliations & Notes
  • Leina Lunasco
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Joseph Roy Abraham
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Kubra Sarici
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Duriye Damla Sevgi
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Annapurna Hanumanthu
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Hasan Cetin
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Ming Hu
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Sunil K. Srivastava
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Jamie Reese
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Justis P Ehlers
    The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, Ohio, United States
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
  • Footnotes
    Commercial Relationships   Leina Lunasco, None; Joseph Abraham, None; Kubra Sarici, None; Duriye Damla Sevgi, None; Annapurna Hanumanthu, None; Hasan Cetin, None; Ming Hu, None; Sunil K. Srivastava, Abbvie (C), Allergan (F), Allergan (C), Eyepoint (F), Eyepoint (C), Eyevensys (F), Eyevensys (C), Gilead (C), Leica (P), Novartis (C), Regeneron (F), Regeneron (C), Santen (F), Zeiss (C); Jamie Reese, None; Justis Ehlers, Adverum (C), Aerpio (F), Aerpio (C), Alcon (F), Alcon (C), Allegro (C), Allergan (F), Allergan (C), Boehringer-Ingelheim (F), Genentech (F), Genentech/Rosche (C), Leica (C), Leica (P), Novartis (F), Regeneron (F), Regeneron (C), Santen (C), Stelath (C), Thrombogenics/Oxurion (F), Thrombogenics/Oxurion (C), Zeiss (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2548. doi:
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      Leina Lunasco, Joseph Roy Abraham, Kubra Sarici, Duriye Damla Sevgi, Annapurna Hanumanthu, Hasan Cetin, Ming Hu, Sunil K. Srivastava, Jamie Reese, Justis P Ehlers; Comparative Assessment of Long-Term Longitudinal Multi-Layer Retinal Dynamics in Non-neovascular Age-Related Macular Degeneration in Eyes Progressing to Subfoveal Geographic Atrophy and Eyes without Progression. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2548.

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Abstract

Purpose : This study evaluates the longitudinal retinal and sub-retinal pigment epithelium (RPE) dynamics on spectral domain optical coherence tomography (SD-OCT) and their associationswith the long-term development of subfoveal geographic atrophy (sfGA) in non-neovascular age-related macular degeneration (AMD).

Methods : This retrospective cohort study compared eyes with non-neovascular AMD without sfGA using macular cube SD-OCT scans available at baseline, year 1, and year 5. Based on disease status at year 5, eyes were classified into one of two subgroups: non-conversion or sfGA converter. Macular cube scans at baseline and year one were evaluated using a machine learning-enhanced multi-layer segmentation software followed by manual verification by expert readers. Outer retinal integrity(e.g., ellipsoid zone (EZ)) and the sub-RPE compartmentmetrics were exported for comparative assessment. T-tests and Wilcoxon signed-rank test were used to compare sfGA converters and non-converters.

Results : One hundred and seventeen eyes were included in this analysis. Baseline mean EZ-RPE volume (i.e., surrogate for photoreceptor outer segment volume) was significantly smaller in the sfGA converter group compared to the non-converter group (0.017 ± 0.008 mm3 vs 0.027 ± 0.006 mm3, p=0.003). In the first year, mean EZ-RPE volume decreased significantly in the sfGA converter group (-0.0067 ± 0.008 mm3, p<0.001) but unchanged in the non-converter group (-0.0007 ± 0.003 mm3). Baseline total EZ attenuation was significantly higher in the sfGA converter group compared to the non-converter group (4.14% vs 0.64%, p<0.001).The baseline RPE-BM volume (i.e., drusen burden) was significantly higher in the sfGAconverter group (compared to the non-converter group (0.045 ± 0.024 mm3 vs. 0.021 ± 0.013 mm3, p=0.001).

Conclusions : Higher order assessment of targeted retinal layer compartments identified significant differences in eyes that developed sfGA compared to eyes that did not over a 5-year period. Specific anatomic features, such as photoreceptor integrity are associated with development of sfGA and should be further explored as potential predictive biomarkers.

This is a 2021 ARVO Annual Meeting abstract.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2023 Association for Research in Vision and Ophthalmology.
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