June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Assessment of macular thickness changes by OCT in asymptomatic relatives of Alzheimer’s disease patients
Author Affiliations & Notes
  • Inés López Cuenca
    Inst.Inv.Oft.Ramón Castroviejo, UCM and RETICs OFTARED-ISCIII, Madrid, Madrid, Spain
  • Rosa de Hoz
    Inst.Inv.Oft.Ramón Castroviejo, UCM and RETICs OFTARED-ISCIII, Madrid, Madrid, Spain
    Departamento de Inmunología, Oftalmología y ORL., Universidad Complutense de Madrid Facultad de Optica y Optometria, Madrid, Comunidad de Madrid, Spain
  • Elena Salobrar-García
    Inst.Inv.Oft.Ramón Castroviejo, UCM and RETICs OFTARED-ISCIII, Madrid, Madrid, Spain
    Departamento de Inmunología, Oftalmología y ORL., Universidad Complutense de Madrid Facultad de Optica y Optometria, Madrid, Comunidad de Madrid, Spain
  • Jose A. Fernández-Albarral
    Inst.Inv.Oft.Ramón Castroviejo, UCM and RETICs OFTARED-ISCIII, Madrid, Madrid, Spain
  • Pilar Rojas
    Inst.Inv.Oft.Ramón Castroviejo, UCM and RETICs OFTARED-ISCIII, Madrid, Madrid, Spain
    , Instituto Oftálmico de Madrid, Hospital General Universitario Gregorio Maranon Unidad de Glaucoma y Neuro-oftalmologia, Madrid, Comunidad de Madrid, Spain
  • Lorena Elvira-Hurtado
    Inst.Inv.Oft.Ramón Castroviejo, UCM and RETICs OFTARED-ISCIII, Madrid, Madrid, Spain
  • Ana Ramirez
    Inst.Inv.Oft.Ramón Castroviejo, UCM and RETICs OFTARED-ISCIII, Madrid, Madrid, Spain
    Departamento de Inmunología, Oftalmología y ORL., Universidad Complutense de Madrid Facultad de Optica y Optometria, Madrid, Comunidad de Madrid, Spain
  • Ana Barabash
    Endocrinology and Nutrition Department, Hospital Clinico Universitario San Carlos, Madrid, Madrid, Spain
    Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas, Madrid, Madrid, Spain
  • Juan J. Salazar
    Inst.Inv.Oft.Ramón Castroviejo, UCM and RETICs OFTARED-ISCIII, Madrid, Madrid, Spain
    Departamento de Inmunología, Oftalmología y ORL., Universidad Complutense de Madrid Facultad de Optica y Optometria, Madrid, Comunidad de Madrid, Spain
  • Jose Ramirez
    Inst.Inv.Oft.Ramón Castroviejo, UCM and RETICs OFTARED-ISCIII, Madrid, Madrid, Spain
    Departamento de Inmunología, Oftalmología y ORL., Universidad Complutense de Madrid Facultad de Medicina, Madrid, Comunidad de Madrid, Spain
  • Footnotes
    Commercial Relationships   Inés López Cuenca, None; Rosa de Hoz, None; Elena Salobrar-García, None; Jose A. Fernández-Albarral, None; Pilar Rojas, None; Lorena Elvira-Hurtado, None; Ana Ramirez, None; Ana Barabash, None; Juan J. Salazar, None; Jose Ramirez, None
  • Footnotes
    Support  Contratos predoctorales de Personal Investigador en Formación. Universidad Complutense de Madrid (UCM).CT42/18‐CT43/18
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2525. doi:
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      Inés López Cuenca, Rosa de Hoz, Elena Salobrar-García, Jose A. Fernández-Albarral, Pilar Rojas, Lorena Elvira-Hurtado, Ana Ramirez, Ana Barabash, Juan J. Salazar, Jose Ramirez; Assessment of macular thickness changes by OCT in asymptomatic relatives of Alzheimer’s disease patients. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2525.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Alzheimer’s diseases is a neurodegenerative disease, whose pathophysiological features show decades before the main cognitive symptoms appear. In addition to age, genetic factors are one of the most important risk factors.
The aim of the present study was to analyze the retinal thickness changes by optical coherence tomography (OCT) in first-degree relatives of Alzheimer’s disease patients who are carriers of ε4 allele for the ApoE, which are two of the main risk factors for developing the disease.

Methods : Sixty- four participants, who were free of ocular pathology were analyzed. A complete eye examination and OCT were performed. The two study groups were formed by 35 subjects with a family history of AD (FH+) and ApoE ε4 carriers and 29 age-matched control subjects without a family history of AD (FH-) and ApoE ε4 non-carriers.

Results : In FH+ ApoE ε4 carriers compared to FH- ApoE ε4 non-carriers we found a statistical significant thinning (p<0.05) in the next sectors and layers: the foveal area of the macular retinal nerve fiber layer (11.89 ± 1.95,FH+ vs 12.86±1.62,FH-); the inferior and nasal sectors, both in the outer (26.77±2.74,FH+ vs 28.17±2.82,FH- for inferior)(29.49±2.89,FH+ vs 30.93±3.85,FH- for nasal) and inner (40.49±2.51,FH+ vs 42.10±3.48,FH- for inferior) (41.94±2.74,FH+ vs 43.52±3.57, FH- for nasal) macular ring in the inner plexiform layer; the foveal area (18.82±3.61, FH+ vs 21.21±3.88,FH-) and the inferior sector in the outer macular ring (30.91±2.72,FH+ vs 32.10±2.81,FH-) in inner nuclear layer, and the inferior sector of the outer macular ring (27.60±2.75,FH+ vs 29.97±3.82,FH-) in outer plexiform layer. No statistically significant differences were found in the peripapillary thickness of RNFL between both study groups.

Conclusions : In asymptomatic relatives of Alzheimer’s disease patients with high genetic risk for the development of AD, initial changes appeared in the macular area. These slight retinal thickness changes measured by OCT could be used as an early biomarker of the disease.

This is a 2021 ARVO Annual Meeting abstract.

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