June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Morphological evaluation of white spots in the granulomatous uveitis using ultra widefield OCT
Author Affiliations & Notes
  • Akira Hayashida
    Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Eiichi Hasegawa
    Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Satoshi Yamana
    Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Mariko Shirane
    Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Takako Ito
    Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Atsunobu Takeda
    Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Nobuyo Yawata
    Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Koh-hei Sonoda
    Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Footnotes
    Commercial Relationships   Akira Hayashida, None; Eiichi Hasegawa, None; Satoshi Yamana, None; Mariko Shirane, None; Takako Ito, None; Atsunobu Takeda, None; Nobuyo Yawata, None; Koh-hei Sonoda, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2501. doi:
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      Akira Hayashida, Eiichi Hasegawa, Satoshi Yamana, Mariko Shirane, Takako Ito, Atsunobu Takeda, Nobuyo Yawata, Koh-hei Sonoda; Morphological evaluation of white spots in the granulomatous uveitis using ultra widefield OCT. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2501.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of this study was to analyze the morphological features of white spots in the peripheral fundus of patients with Sarcoidosis and Vogt-Koyanagi-Harada disease (VKH), which are classified as granulomatous uveitis.

Methods : Sarcoidosis and VKH patients in Kyushu University Hospital, who had white spots in the periphery of the fundus, were enrolled in the study. Images of the white spots were obtained using Optos® Silverstone, ultra-widefield guided swept source optical coherence tomography (OCT).
We compared the morphological characteristics of those white spots between the two diseases.

Results : OCT Images of white spots were obtained from 13 patients with Sarcoidosis and 9 patients with VKH. Atrophic lesions were observed in 10 cases of Sarcoidosis and 9 cases of VKH, all of which had retinal pigment epithelial (RPE) defects with no morphological differences between diseases. In both diseases, subretinal elevated lesions were seen in some cases (Sarcoidosis; 5 cases, VKH; 3 cases). Those lesions were Dalen-Fuchs nodule-like elevated lesions with RPE perforation or Sarcoid nodule-like lesions under the RPE without RPE perforation. In contrast, hyperreflective lesions in the retina were found only in Sarcoidosis (7 cases), but not in VKH.

Conclusions : The site of the white spots in the peripheral fundus varied, suggesting that each disease have a different morphological pattern.

This is a 2021 ARVO Annual Meeting abstract.

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