June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Effects of Liposome-encapsulated Ripasudil on Proliferative Vitreoretinopathy
Rui Ji; Keijiro Ishikawa; Kenichiro Mori; Naoya Matsunaga; Iori Wada; Takahito Nakama; Shintaro Nakao; Shigehiro Ohdo; Koh-hei Sonoda
Author Affiliations & Notes
  • Rui Ji
    Department of Ophthalmology，Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Keijiro Ishikawa
    Department of Ophthalmology，Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Kenichiro Mori
    Department of Ophthalmology，Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Naoya Matsunaga
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Iori Wada
    Department of Ophthalmology，Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Takahito Nakama
    Department of Ophthalmology，Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Shintaro Nakao
    Department of Ophthalmology，Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Shigehiro Ohdo
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Koh-hei Sonoda
    Department of Ophthalmology，Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
  • Footnotes
    Commercial Relationships   Rui Ji, None; Keijiro Ishikawa, None; Kenichiro Mori, None; Naoya Matsunaga, None; Iori Wada, None; Takahito Nakama, None; Shintaro Nakao, None; Shigehiro Ohdo, None; Koh-hei Sonoda, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3622. doi:
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      Rui Ji, Keijiro Ishikawa, Kenichiro Mori, Naoya Matsunaga, Iori Wada, Takahito Nakama, Shintaro Nakao, Shigehiro Ohdo, Koh-hei Sonoda; Effects of Liposome-encapsulated Ripasudil on Proliferative Vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3622.

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Abstract

Purpose : We previously reported ROCK inhibitor, Ripasudil could inhibit epithelial to mesenchymal transition of retinal pigment epithelium (RPE). The purpose of this study was to investigate the inhibitory effects of liposome-encapsulated Ripasudil (Lipo-Ripa) on an animal model of proliferative vitreoretinopathy (PVR).

Methods : PVR was induced in the eyes of Dutch rabbits as previously reported. After PVR induction, we performed single vitreous injection of BSS (control), Ripasudil (Ripa) and Lipo-Ripa in each group. We collected the vitreous fluid at 6 h, 24 h and 48 h after injection and measured the concentration of Ripasudil. PVR progression was observed by fundus camera and the stage was graded.

Results : Vitreous concentration of Ripasudil was significantly higher (4-32 times) in Lipo-Ripa group compared to Ripa group over time. In Ripa group, PVR progression was significantly suppressed on day 7 and 14 compared to control group (p<0.05). In Lipo-Ripa group, PVR progression was significantly suppressed on day 7, 14 ,21 and 28 (p<0.05).

Conclusions : Lipo-Ripa could efficiently suppress PVR progression by its prolonged residency in the vitreous.

This is a 2021 ARVO Annual Meeting abstract.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2024 Association for Research in Vision and Ophthalmology.
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