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Grace Xiao, Aleksandra Mihailovic, Jian-Yu E, Sheila K West, David S Friedman, Laura N. Gitlin, Pradeep Y Ramulu; Association Between Over Time Changes in Visual Field and Contrast Sensitivity in Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3538.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the association between changes in visual field [VF] and contrast sensitivity [CS] in glaucomatous eyes over a 3-year study period.
Glaucoma patients who underwent a minimum of three Humphrey 24-2 SITA-Standard VFs and three MARS CS tests were evaluated. Univariate linear regression was used to calculate within-eye slopes of changes in VF mean deviation (MD) and CS over time. Multivariable generalized estimating equation models accounting for within-individual clustering were used to assess the relationship between MD and CS at the baseline and changes over time. Change in concordance/discordance between MD and CS in terms of defining the eye with better vision was evaluated over time using the test of proportions and survival analysis. Agreement of better eye MD / CS in defining longitudinal stability (±0.5 dB/year for MD and ±0.04 logCS units/year for CS) vs. change was also examined.
338 eyes from 180 glaucoma patients were included. Participants were on average 70 years old and about a third of participants were Black and half were female. There was a significant association between MD and CS at baseline (ß=1.53 dB decline for every 0.1 logCS unit decline, p<0.001) and change in MD and CS over time (ß=0.13 dB decline for every 0.1 logCS unit decline, p= 0.002). At baseline, MD and CS tests did not identify the same eye as the better eye for 33.8% of patients. 50% of eyes that were discordant at baseline remained discordant (95% confidence interval (CI) = 0.34-0.66) while 80% of eyes concordant at baseline remained concordant (95% CI = 0.71-0.89). At the end of 3 years, the probability of concordant eyes at baseline remaining concordant over time was 66%, significantly greater than the probability of discordant eyes at baseline remaining discordant (p<0.001). Over the 3-year period, 77% of subjects who had stable better eye MD also had stable CS while 45% of subjects who had worsening better eye MD also had worsening CS. Similarly, 83% of subjects who had stable CS over the years also had stable MD while 37% of subjects who had worsening CS also had worsening MD.
We found that change in CS over time predicts change in MD in those with glaucoma. However, more work is required to determine if CS could serve as an ancillary test to help judge disease progression.
This is a 2021 ARVO Annual Meeting abstract.
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