June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Remote Longitudinal Monitoring of Glaucoma Using Virtual Reality-Based Oculokinetic Perimetry
Author Affiliations & Notes
  • Marcus L Turner
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Zer Keen Chia
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Anwell Nguyen
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Alan W Kong
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Benjamin T Backus
    Vivid Vision, California, United States
  • Michael Deiner
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Yvonne Ou
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Marcus Turner, None; Zer Keen Chia, None; Anwell Nguyen, None; Alan Kong, None; Benjamin Backus, Vivid Vision (E); Michael Deiner, None; Yvonne Ou, None
  • Footnotes
    Support  UCSF Summer Explore Research Grant, UCSF Resource Allocation Program, NIH-NEI P30 EY002162 Core Grant for Vision Research and an unrestricted grant from Research to Prevent Blindness, New York, NY
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3484. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Marcus L Turner, Zer Keen Chia, Anwell Nguyen, Alan W Kong, Benjamin T Backus, Michael Deiner, Yvonne Ou; Remote Longitudinal Monitoring of Glaucoma Using Virtual Reality-Based Oculokinetic Perimetry. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3484.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Virtual reality-based oculokinetic perimetry (VR-OKP) is a mobile, short, screening visual field test. The purpose of this study is to examine whether VR-OKP could be implemented in a remote fashion and used to assess the stability of the visual field.

Methods : Glaucoma subjects with known glaucomatous defects who had taken an in-person VR-OKP test in 2019 were re-enrolled and underwent the same test remotely in 2020. An exit survey comparing patients’ preferences for visual field testing was also conducted remotely. Subjects underwent Humphrey visual field 24-2 (HVF) testing within 3 months of VR-OKP both in 2019 and 2020. For unadjusted comparisons between HVF and VR-OKP, we compared mean sensitivities and fraction of points. A non-parametric bootstrap analysis that resampled eyes with replacement was done to calculate the 95% confidence interval of the Spearman correlation coefficient between HVF sensitivity versus VR-OKP fraction seen at each point of the 54 test locations.

Results : The cohort consisted of 19 eyes of 11 patients (55% female, 73% Caucasian, 27% Asian, mean age 61.4 ± 12.6 yrs) with moderate to advanced glaucoma (2020 average HVF mean deviation -4.23 dB ± 5.12). VR-OKP from 2019 to 2020 had a decreased mean percent change of -6.31% ± 17.22 (p=0.13) compared to HVF testing from 2019 to 2020 which had an increased mean change of mean deviation of +2.41 dB ± 1.35 (p<.00005). The Pearson’s Correlation Coefficient between 2019 VR-OKP fraction seen and 2019 HVF mean sensitivity was 0.74, while it was 0.56 in 2020. Spearman correlation coefficients of HVF sensitivity vs VR-OKP fraction seen at each point ranged from -0.01-0.86 (median = 0.33). Subjects found VR-OKP to be as comfortable as HVF (p=0.8) and less fatiguing (p=0.03).

Conclusions : This study highlights the feasibility of a remote option for visual field assessment. The correlation between VR-OKP and HVF in 2019 was higher than in 2020. One explanation is that the 2019 test was taken with in-person instruction, whereas the 2020 test was administered remotely. While the mean percentage change in VR-OKP was non-significant, the 2019 to 2020 change in HVF was statistically significant and showed improvement, which may be due to long term fluctuation. This short VR-OKP test is less fatiguing to patients, can detect non-progression even when taken at home, and could potentially be deployed to decrease patients’ risk of COVID-19.

This is a 2021 ARVO Annual Meeting abstract.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×