Abstract
Purpose :
Wide biologic variability and inconclusive Optical Coherence Tomography (OCT) detection of disc margin limit accurate representation of optic nerve head (ONH) disc area (DA). This cross-sectional study assesses the relationship between Pattern Electroretinogram (PERG) and OCT derived ONH measurements after controlling for DA.
Methods :
Sixteen pre-perimetric glaucoma (PPG) subjects (thirty eyes) with normal Humphrey 24-2 visual field tests and suspicious ONH were consecutively recruited at Manhattan Eye Ear and Throat Hospital. Participants underwent Diopsys NOVA PERG and Cirrus and Spectralis OCT tests. Partial correlation analysis was conducted between PERG (Magnitude [Mag], MagnitudeD [MagD] and Magnitude D/Magnitude ratio [MagD/Mag ratio]) and ONH measurements (Rim Area and Bruch’s Membrane Opening-Minimum Rim Width [MRW]), after controlling for DA. Hierarchical multiple regression analysis was used to determine the ability of PERG to predict variance in rim area and MRW global measurement after controlling for DA.
Results :
After controlling for DA, partial correlation analysis showed a significant correlation between Mag, MagD and rim area, (r>0.503, p<0.005). Similarly, Mag, MagD and MagD/Mag ratio were significantly correlated with MRW temporal superior (MRW-TS) (r>0.400, p<0.039), and with MRW nasal inferior (MRW-NI) (r>0.431, p<0.025) sectors. MagD and MagD/Mag ratio significantly correlated with MRW global (r>0.407, p<0.035).
In two separate hierarchal linear regression models, in the prediction of rim area, after controlling for DA (step 1), Mag then MagD (step 2) explained an additional 26.8% and 25.2 % of variance in rim area (B=0.174 [95% CI: 0.065, 0.283], P<0.005) and (B= 0.160 [95% CI: 0.056, 0.265], P<0.005), respectively.
In prediction of MRW global, after controlling for DA (step 1), MagD then MagD/Mag ratio (step 2) explained an additional 13.4% and 12.8% of the variance in MRW global, (B= 38.921[95% CI: 3.872,73.970], P<0.05) and (B=129.024 [95% CI: 9.589, 248.460], P<0.05), respectively.
Conclusions :
PERG can predict variance not only in rim area and global MRW, but also in MRW-TS and MRW-NI sectors, after controlling for DA. This highlights the benefit of using PERG in addition to OCT ONH morphology measurements to increase diagnostic accuracy for early glaucoma diagnosis.
This is a 2021 ARVO Annual Meeting abstract.