Abstract
Purpose :
Evaluating the influence of perimetric parameters at abnormal points within the central 10 degree in 24-2 VF on the severity of10-2 VF in early glaucoma(MD<-7dB).
Methods :
This cross-sectional study included 54 eyes of 49 early glaucoma patients with central visual field defect (CVFD) on 24-2 VF and related parafoveal scotomas on10-2 VF. CVFD, a glaucomatous defect with at least 1 abnormal 24-2 VF point, depressed P<1% in the central 10 degrees (12 points:central-most 4 points and paracentral 8 points) on 3 consecutive tests either on total deviation (TD) or pattern deviation (PD) plot. Based on pattern defects,10-2 VFs were categorized into 3: arcuate, partial arcuate and minimal defect groups, the arcuate defect being the most severe form. We compared the perimetric parameters differences between 24-2VFs with central-most VF defects (CMVFD) or paracentral defects and related 10-2 VFs. We assessed the relationship between various perimetric factors at abnormal 24-2 VF points (central 4 and paracentral 8 points) and the severity of 10-2 VF using Pearson’s correlation coefficients.
Results :
The mean age of the population was 67.6 years and mean 24-2 mean deviation (MD)-3.76dB. On 24-2 VF, 4(7.4%) eyes had only CMVFDs,31(57.4%) had both CMVFDs and paracentral defects and19(35.1%) had paracentral defects. On 10-2 VF, 25(46%) eyes displayed arcuate defect,11(20%) partial arcuate and 18(33%) minimal defect. Arcuate group had worse MD,PSD (pattern standard deviation) than partial arcuate and minimal defect groups(P<.001).High defect depth(>-25dB) and low threshold sensitivity (<0 to10dB) at abnormal 24-2 VF points were significantly associated with the presence of arcuate defect on the 10-2 test (P=0.033; P=0.002).PSD in arcuate group on the 10-2 test displayed negative correlation with threshold sensitivity(-0.638,P=0.003) and defect depth[(TD: -0.765, P<.001);(PD: -0.542,P=0.037)] of abnormal central-most 4 points in 24-2 VF.
Conclusions :
High defect depth and low threshold sensitivity at abnormal points within the central-most 4 and/or para-central 8 points in 24-2 VF are significantly associated with the presence of arcuate defect on10-2 VF. Clinicians might consider measuring perimetric parameters at abnormal 24-2VFpoints within the central10 degrees to predict the severity and functional impacts of central glaucomatous visual field loss.
This is a 2021 ARVO Annual Meeting abstract.