June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Real-time temperature controlled cw-laser treatment in rabbits
Author Affiliations & Notes
  • Jan-Erik Fleger
    Department of Ophthalmology, Christian-Albrechts-Universitat zu Kiel Medizinische Fakultat, Kiel, Schleswig-Holstein, Germany
  • Claus von der Burchard
    Department of Ophthalmology, Christian-Albrechts-Universitat zu Kiel Medizinische Fakultat, Kiel, Schleswig-Holstein, Germany
  • Christopher Kren
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Mario Mordmüller
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Dirk Theisen-Kunde
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Veit Danicke
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Hossam Abbas
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Ralf Brinkmann
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Johann Roider
    Department of Ophthalmology, Christian-Albrechts-Universitat zu Kiel Medizinische Fakultat, Kiel, Schleswig-Holstein, Germany
  • Footnotes
    Commercial Relationships   Jan-Erik Fleger, None; Claus von der Burchard, None; Christopher Kren, None; Mario Mordmüller, None; Dirk Theisen-Kunde, None; Veit Danicke, None; Hossam Abbas, None; Ralf Brinkmann, None; Johann Roider, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3309. doi:
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      Jan-Erik Fleger, Claus von der Burchard, Christopher Kren, Mario Mordmüller, Dirk Theisen-Kunde, Veit Danicke, Hossam Abbas, Ralf Brinkmann, Johann Roider; Real-time temperature controlled cw-laser treatment in rabbits. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3309.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Laser photocoagulation is widely used in retinal treatment. However, the tissue effect is only partially correlated to laser energy due to inter- and intraindividual alterations in retinal pigment epithelium (RPE) pigmentation. This leads to wide variations in laser effect and decreases treatment reliability and reproducibility. Optoacoustic measurement and control of retina temperature can solve this problem by adjusting the laser power in real-time onto a target temperature. With this temperature-guided irradiation, reliable and reproducible laser-tissue effect can be achieved for non-damaging heating. The aim of the study is to validate a control module by measuring and controlling laser power and real-time temperatures.

Methods : 5 eyes of 3 rabbits received a retinal temperature regulated laser treatment with a conventional 532nm continuous wave (cw) laser (Zeiss VisuLas 532). A custom-build control module (Medical Laser Center Luebeck) was used, which is optically coupled between the treatment laser and the slit lamp. It adjusts the pre-set laser power, depending on the current tissue temperature. Per pre-marked areal (5-6 in each eye) nine 200µm lesions (100ms exposure time) with uprising temperatures (45°C to 69°C in steps of 3°C) were applied. The mean applied laser power and mean real-time temperature over the last 20ms were measured.

Results : For the same target temperature, the controlled laser power showed significant differences. The following shows the mean applied laser power (± standard deviation and max/min values) over the last 20ms of irradiation for the target temperatures 51°C (14.8mW ± 7.2, 31.0mW/0.9mW), 60°C (24.6mW ± 9.3, 42.4mW/2.2mW) and 69°C (35.00mW ± 12.8, 56.8mW/4.6mW). The real-time temperature displayed an overall accuracy of 3.5 % to the pre-set target temperature over the last 20ms of irradiation.

Conclusions : The results demonstrate that the control module was able to achieve reproducible and reliable real-time temperature-controlled irradiation. This will allow for more consistent subvisible laser treatment.

This is a 2021 ARVO Annual Meeting abstract.

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