June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Macular Pigment Changes in eyes implanted with yellow-tinted intraocular lens
Author Affiliations & Notes
  • Akira Obana
    Ophthalmology, Seirei Hamamatsu Byoin, Hamamatsu, Shizuoka, Japan
    Photochemical Medicine Department, Hamamatsu Ika Daigaku, Hamamatsu City, Shizuoka, Japan
  • Yuko Gohto
    Ophthalmology, Seirei Hamamatsu Byoin, Hamamatsu, Shizuoka, Japan
  • Ryo Asaoka
    Ophthalmology, Seirei Hamamatsu Byoin, Hamamatsu, Shizuoka, Japan
  • Footnotes
    Commercial Relationships   Akira Obana, Alcon (F), Alteck (C); Yuko Gohto, None; Ryo Asaoka, Haag-Streit (F), Kowa (F), Nidek (F), Oculus (F), Reihert (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3288. doi:
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    • Get Citation

      Akira Obana, Yuko Gohto, Ryo Asaoka; Macular Pigment Changes in eyes implanted with yellow-tinted intraocular lens. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3288.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We previously reported that macular pigment optical density (MPOD) levels decreased during a long follow-up period after clear intraocular lens (IOL) implants surgery presumably due to excessive light exposure (Obana et al. Ophthalmol 2011;118). In the present study, we examined changes in MPOD levels after cataract surgery with yellow-tinted IOL implantation using a different technique to measure MPOD from the previous study.

Methods : This is a prospective, observational study under approval by institutional review board. Subjects were 55 eyes of 35 patients. MPOD levels were measured by a SPECTRALIS OCT (Heidelberg Engineering Inc.) equipped with a dual-wavelength autofluorescence technique on day 4, months 1, 3, and 6, and years 1 and 2 postoperatively. The average optical densities at 0°, 0.5°, 0.9°, and 2° eccentricities (local MPODs) and total MPOD volumes in the area within 9° eccentricity (MPOV) were analyzed.

Results : The mean local MPOD at baseline (on day 4) was 0.79 at 0°, 0.71 at 0.5°, 0.68 at 0.9°, and 0.32 at 2°. The mean MPOV within 1.5° and 9° at baseline was 2950 and 18897, respectively. Local MPOD at 0.9° and 2° and MPOV slightly decreased on month 1 and increased after that. The increase reached statistical significance in local MPOD at 0.5° and 2° and MPOV within 1.5° and 9° on year 2 (Tukey-Kramer test). The change rates of MPOV within 9° on year 2, ((MPOV on year 2 – MPOV on day 4) / MPOV on day 4), were from -0.21 to 1.18 (mean and standard deviation: 1.14±0.28). The MPOV of fifteen eyes increased more than 10% from the initial value, was maintained within 10% in 21 eyes and deteriorated more than 10% in only 3 eyes.

Conclusions : Local MPOD and MPOV tended to slightly decrease at month 1 postoperatively and gradually increase after that, but the increase rates of MPOD levels were small compared to the previous report (Nolan et al. IOVS2009;50). Yellow-tinted IOL that has lower transmittance of blue light might be preferable in the respect of preserving MPOD levels after surgery.

This is a 2021 ARVO Annual Meeting abstract.

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