June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Transcorneal electrical stimulation slows down visual field decline in retinitis pigmentosa in a current-strength-dependent manner
Author Affiliations & Notes
  • Alfred Stett
    Okuvision GmbH, Reutlingen, Germany
  • Andreas Schatz
    Centre for Ophthalmology, University Eye Hospital, Eberhard Karls Universitat Tubingen, Tubingen, Baden-Württemberg, Germany
  • Florian Gekeler
    Department of Ophthalmology, Klinikum Stuttgart Katharinenhospital, Stuttgart, Baden-Württemberg, Germany
  • Jeremy Franklin
    Institute of Medical Statistics and Computational Biology, University of Cologne, Koeln, Germany
  • Footnotes
    Commercial Relationships   Alfred Stett, Okuvision GmbH (E); Andreas Schatz, None; Florian Gekeler, None; Jeremy Franklin, Okuvision GmbH (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3239. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Alfred Stett, Andreas Schatz, Florian Gekeler, Jeremy Franklin; Transcorneal electrical stimulation slows down visual field decline in retinitis pigmentosa in a current-strength-dependent manner. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3239.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Transcorneal electrical stimulation (TcES) is a clinically available method to slow down disease progression in retinitis pigmentosa (RP). We hypothesize that the effect of TcES on the rate of visual field loss obeys a dose-response relationship with current strength.

Methods : In a prospective, randomized study (clinicaltrials.gov: NCT01837901), one eye of each of 52 subjects with RP was transcorneally stimulated weekly for 30 minutes over a period of 52 weeks with biphasic current pulses (OkuStim, maximum 1.2 mA, 5 ms each phase, 20 Hz). The visual field areas (VFA) were repeatedly assessed in both eyes (Octopus 900, Goldman targets III4e, V4e). Stimulation current strength was 0% (sham), 150% and 200% of the patient’s electrical phosphene threshold in 3 randomized groups of patients, respectively. In addition to the primary analysis, where the effect of TcES on the stimulated eyes was analyzed in relation to randomized group (Schatz et al., IOVS, 2017, 58:1), in the now presented secondary analysis, the percentage reductions of the VFA of the stimulated (R1) and non-stimulated eyes (R0) after 52 weeks of stimulation were analyzed in relation to the actual current strength. Mean current strength over 52 weeks stimulation was analyzed both as a continuous variable (linear regression) and an ordinal variable (5 classes, Jonckheere-Terpstra test).

Results : As the current strength increased, the VFA (V4e) decreased more slowly, whereby there was a significant linear relationship (p = 0.049) and a significant ordinal relationship (p = 0.011) between the differences in percentage reduction, (R1 – R0), and the current strength. In the eyes stimulated with more than 0.8 mA (n = 9), R1 was 0.7% ± 7.2% (mean ± SD) compared with R0 of 8.8% ± 9.1% in the non-stimulated fellow eyes (difference between both eyes: p = 0.098, Wilcoxon signed rank test). In the sham group (n = 20) the mean percentage reductions R1 and R0 were 7.0% ± 11.1% and 7,0% ± 16.1%. Analysis of VFA III4e yielded in no signifcant effect of TcES.

Conclusions : Our results are consistent with the hypothesis that by TcES the decline in VFA in patients with RP can be slowed significantly in a current-strength-dependent manner. Furthermore, they provide additional evidence that TcES is an efficient method that can stop or delay the disease progression in RP.

This is a 2021 ARVO Annual Meeting abstract.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×