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Yu-Yen Chen, Tzu-Chen Lo; Patients with retinitis pigmentosa may have a higher risk of developing primary angle-closure glaucoma and open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3210.
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To investigate whether patients with retinitis pigmentosa (RP) have a higher proportion of primary angle-closure glaucoma (PACG) and open-angle glaucoma (OAG) development.
Using the Taiwan National Health Insurance Research Database from 2001 to 2013, patients with RP were enrolled into the RP group and age- and gender-matched individuals without RP (1:4 matched) were enrolled into the control group. Kaplan-Meier curves were generated to compare the cumulative hazard of subsequent PACG and OAG between the two groups. A Cox regression analysis was performed to estimate the crude and adjusted hazard ratios (HRs) for PACG and OAG.
6223 patients with RP and 24892 controls were enrolled. During the 13-year study period, 1.61% of RP patients and 0.81% of controls developed PACG (p value < 0.0001). Besides, more proportion of RP patients developed OAG than controls did (1.57% vs. 0.58%, p value < 0.0001). RP group had a significantly higher cumulative hazard of PACG and OAG compared to the control group (p value < 0.0001). The Cox regression model indicated that the RP group had a significantly higher risk for PACG and OAG (adjusted HR= 2.04 and 2.83, respectively).
Patients with RP are at significantly greater risk of developing PACG and OAG.
This is a 2021 ARVO Annual Meeting abstract.
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