June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Clinical characteristics of and treatment trends for submacular hemorrhage: a retrospective multicenter survey in Japan
Author Affiliations & Notes
  • Takeshi Kimura
    Hyogo Ika Daigaku Byoin, Nishinomiya, Hyogo, Japan
  • Takashi Araki
    Hyogo Ika Daigaku Byoin, Nishinomiya, Hyogo, Japan
  • Tsutomu Yasukawa
    Nagoya Shiritsu Daigaku Byoin, Nagoya, Aichi, Japan
  • Soichiro Kuwayama
    Nagoya Shiritsu Daigaku Byoin, Nagoya, Aichi, Japan
  • Takamasa Kinoshita
    Shiritsu Sapporo Byoin, Sapporo, Hokkaido, Japan
  • Fumiki Okamoto
    Tsukuba Daigaku Igaku Iryokei, Tsukuba, Ibaraki, Japan
  • Yoshinori Mitamura
    Tokushima Daigaku Byoin, Tokushima, Tokushima, Japan
  • Taiji Sakamoto
    Kagoshima Daigaku Byoin, Kagoshima, Kagoshima, Japan
  • Akiko Miki
    Kobe Daigaku Igakubu Fuzoku Byoin, Kobe, Hyogo, Japan
  • Yoshihiro Takamura
    Fukui Iryo Daigaku, Fukui, Fukui, Japan
  • Hisashi Matsubara
    Mie Daigaku Igakubu Fuzoku Byoin, Tsu, Mie, Japan
  • Hiroki Tsujinaka
    Nara Kenritsu Ika Daigaku Fuzoku Byoin, Kashiwara, Nara, Japan
  • Fumi Gomi
    Hyogo Ika Daigaku Byoin, Nishinomiya, Hyogo, Japan
  • Footnotes
    Commercial Relationships   Takeshi Kimura, None; Takashi Araki, None; Tsutomu Yasukawa, None; Soichiro Kuwayama, None; Takamasa Kinoshita, None; Fumiki Okamoto, None; Yoshinori Mitamura, None; Taiji Sakamoto, None; Akiko Miki, None; Yoshihiro Takamura, None; Hisashi Matsubara, None; Hiroki Tsujinaka, None; Fumi Gomi, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3172. doi:
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    • Get Citation

      Takeshi Kimura, Takashi Araki, Tsutomu Yasukawa, Soichiro Kuwayama, Takamasa Kinoshita, Fumiki Okamoto, Yoshinori Mitamura, Taiji Sakamoto, Akiko Miki, Yoshihiro Takamura, Hisashi Matsubara, Hiroki Tsujinaka, Fumi Gomi; Clinical characteristics of and treatment trends for submacular hemorrhage: a retrospective multicenter survey in Japan. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3172.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To determine the current clinical characteristics and the trends in treatment for submacular hemorrhage (SMH) in Japan.

Methods : The inclusion criteria were subfoveally involved SMH more than 2 optic discs in area, followed for at least 2 months. One hundred eighty-four (184) eyes of 184 patients (104 men and 80 women) were enrolled from 10 hospitals. The characteristics of SMH were classified by the FLATCAPS classification. Causes, selected treatments, and pre- and post-treatment best-corrected visual acuity (BCVA) were analyzed.

Results : The patients’ mean age was 76.1 ± 9.2. SMH was caused by retinal arterial macroaneurysm (RAM) in 52 eyes (28%), and by age-related macular degeneration (AMD) in 127 eyes (69%): typical age-related macular degeneration in 26%, polypoidal choroidal vasculopathy (PCV) in 73%, and retinal angiomatous proliferation (RAP) in 1%. SMH was observed in more than two retinal layers in 60% of the RAM group and in the subretinal and sub-RPE spaces in 106 eyes (83%) of the AMD group. The mean period between onset and treatment was 10.9 days in all cases, and more cases underwent vitrectomy in the RAM group than in the AMD group (P < 0.0001). Subretinal tissue plasminogen activator injection was selected for 49% of the vitrectomy cases. Mean BCVA in the AMD group was significantly better than in the RAM group at baseline, 1 month after treatment, and the final visit (P>0.0001, P>0.0026, P>0.0163).

Conclusions : PCV was about twice as frequent as RAM as the cause of SMH. The RAM group included more cases with vitrectomy than the AMD group and showed poor BCVA.

This is a 2021 ARVO Annual Meeting abstract.


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