Abstract
This abstract has been retracted. :
Purpose :
The presence of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR) separates the photoreceptors from the blood supply of the choroid, which could lead to disruptions of the cells in the outer retina especially when CSCR is chronic or recurrent. In this retrospective study, we sought to determine the functional and anatomical outcomes of CSCR based on standard treatment methods as well as experimental normobaric hyperoxia (NBH), which has been proposed to reduce macular edema and improve vision.
Methods :
Clinical outcomes and ocular coherence tomography findings were compared for patients with CSCR undergoing observation, laser/photodynamic therapy (PDT), or NBH. A total of 47 patients with active CSCR, acute (≤6 months) or chronic (>6 months), were included and underwent either observation (n=23), laser/PDT therapy (n=7), 3-hour NBH sessions (n=13), or nocturnal NBH (n=4). Best corrected visual acuity (BCVA), recurrence, and the thickness of the central macula (CMT), SRF, photoreceptor layer (PL), and outer nuclear layer (ONL) were assessed.
Results :
A total of 49 eyes were classified as acute (n=39) or chronic (n=16) and non-recurrent (n=26) or recurrent (n=15). Time for complete resolution of SRF was 3.5±1.5 months for acute patients and 11±4.2 months for chronic patients. BCVA improved from baseline for all resolving patients regardless of treatment type. None of the patients in the laser therapy group experienced a recurrent episode after an average follow-up of 38.7±19.7 months (range of 3.6 – 56.6 months) while 48% of observation-only patients experienced a recurrence within an average of 24.9±23.7 months (range of 1.7 to 68.8 months). Patients in the 3hr NBH group showed no statistical difference in any of the parameters tested before and after treatment. When compared to observation patients, resolving nocturnal NBH patients demonstrated a decrease in the time for resolution of SRF (4.5±3.1 and 3.8 months, respectively). In resolving patients, there were consistent decreases in CMT and PL thickness, and little to no change in the thickness of the ONL.
Conclusions :
We show that patients with CSCR have a high probability of recurrence and that this may be reduced by laser/PDT therapy. Nocturnal NBH may facilitate earlier resolution of SRF and vision loss. Together, these treatment strategies may improve clinical outcomes for CSCR.
This is a 2021 ARVO Annual Meeting abstract.