June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Racial differences in outcomes of retinal detachment repair following pars plana vitrectomy in the postoperative period: A TriNetX Analysis
Author Affiliations & Notes
  • Masumi Asahi
    Ophthalmology, George Washington University Medical Faculty Associates, Washington, District of Columbia, United States
  • Haig Pakhchanian
    The George Washington University, Washington, District of Columbia, United States
  • Rahul Raiker
    West Virginia University School of Medicine, Morgantown, West Virginia, United States
  • Sunil Bellur
    Ophthalmology, George Washington University Medical Faculty Associates, Washington, District of Columbia, United States
  • Chloe T.L. Khoo
    Ophthalmology, George Washington University Medical Faculty Associates, Washington, District of Columbia, United States
  • H Nida Sen
    National Eye Institute, Bethesda, Maryland, United States
  • Shilpa Kodati
    National Eye Institute, Bethesda, Maryland, United States
  • Footnotes
    Commercial Relationships   Masumi Asahi, None; Haig Pakhchanian, None; Rahul Raiker, None; Sunil Bellur, None; Chloe Khoo, None; H Nida Sen, None; Shilpa Kodati, None
  • Footnotes
    Support  The Richard A Falls Research Grant #2020 F through the Virginia Lions Eye Institute Foundation
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3093. doi:
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      Masumi Asahi, Haig Pakhchanian, Rahul Raiker, Sunil Bellur, Chloe T.L. Khoo, H Nida Sen, Shilpa Kodati; Racial differences in outcomes of retinal detachment repair following pars plana vitrectomy in the postoperative period: A TriNetX Analysis. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3093.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare race-related differences in outcomes following pars plana vitrectomy (PPV) for retinal detachment (RD) in the postoperative period between individuals of black and white descent.

Methods : A retrospective cohort study was conducted using TriNetX (Cambridge, MA, USA), a federated electronic health records research network comprising multiple large health organizations in the United States. Patients who underwent PPV for RD were identified by CPT code and stratified into black and white cohorts. Cohorts were matched for age, gender, and medical comorbidities (hypertension, diabetes mellitus, cerebrovascular disease, heart failure, nicotine dependence, alcohol related disorders, and body mass index). The primary outcomes were: retinal tear (RT), RD with retinal break, serous RD, epiretinal membrane (ERM), macular edema (ME), cataract, macular hole (MH), macular degeneration, papilledema, retinal vein occlusion (RVO), retinal artery occlusion (RAO), conjunctivitis, dry eye, optic neuritis, other disorders of optic nerve, decompression of the orbit, and endophthalmitis. Outcomes were compared between the cohorts after propensity score matching using logistic regression and greedy nearest-neighbor matching algorithm.

Results : A total of 3,516 patients were included in analysis with 1,758 in each of the black and white cohorts after propensity matching. The white cohort had a significant greater risk of developing RT (RR, 0.47; 95% CI, 0.26-0.85), RD with retinal break (RR,0.76; 95% CI, 0.7-0.82), serous RD (RR, 0.65; 95% CI, 0.58-0.73), ERM (RR, 0.52; 95% CI, 0.34-0.79), ME (RR, 0.47; 95% CI, 0.28-0.77), and cataract (RR, 0.56; 95% CI, 0.39-0.8) whereas the black cohort had a significant greater risk of developing a MH (RR, 1.74; 95% CI, 1.2-2.53). No significant difference was seen in rate of development of macular degeneration, papilledema, RVO, RAO, conjunctivitis, dry eye, optic neuritis, other disorders of optic nerve, decompression of the orbit, or endophthalmitis between the black and white cohorts.

Conclusions : Race is an important consideration when evaluating for complications following PPV for RD. Whites were more likely to develop RD, ERM, ME, and cataracts whereas blacks were more likely to develop MH. These differences should be considered when evaluating and discussing outcomes with patients both pre and post-operatively.

This is a 2021 ARVO Annual Meeting abstract.

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