August 2021
Volume 62, Issue 11
Open Access
ARVO Imaging in the Eye Conference Abstract  |   August 2021
Analysis of central macular thickness in patients with dry Age related Macular Degenaration and cardiovascular risk factors
STAVROULA ALMPANIDOU; Diamantis Almaliotis; Eleni Papadopoulou; Leonidas Karamitopoulos; Fotios Topouzis; Vasileios Karampatakis
Author Affiliations & Notes
  • STAVROULA ALMPANIDOU
    Laboratory of Experimental Ophthalmology, School of Medicine, Aristoteleio Panepistemio Thessalonikes, Thessaloniki, Central Macedonia, Greece
  • Diamantis Almaliotis
    Laboratory of Experimental Ophthalmology, School of Medicine, Aristoteleio Panepistemio Thessalonikes, Thessaloniki, Central Macedonia, Greece
  • Eleni Papadopoulou
    Laboratory of Experimental Ophthalmology, School of Medicine, Aristoteleio Panepistemio Thessalonikes, Thessaloniki, Central Macedonia, Greece
  • Leonidas Karamitopoulos
    Laboratory of Experimental Ophthalmology, School of Medicine, Aristoteleio Panepistemio Thessalonikes, Thessaloniki, Central Macedonia, Greece
  • Fotios Topouzis
    Laboratory of Experimental Ophthalmology, School of Medicine, Aristoteleio Panepistemio Thessalonikes, Thessaloniki, Central Macedonia, Greece
  • Vasileios Karampatakis
    Laboratory of Experimental Ophthalmology, School of Medicine, Aristoteleio Panepistemio Thessalonikes, Thessaloniki, Central Macedonia, Greece
  • Footnotes
    Commercial Relationships   STAVROULA ALMPANIDOU, European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code:T1EDK-03742) (F); Diamantis Almaliotis, European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code:T1EDK-03742) (F); Eleni Papadopoulou, European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code:T1EDK-03742) (F); Leonidas Karamitopoulos, European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code:T1EDK-03742) (F); Fotios Topouzis, European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code:T1EDK-03742) (F); Vasileios Karampatakis, European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code:T1EDK-03742) (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science August 2021, Vol.62, 62. doi:
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      STAVROULA ALMPANIDOU, Diamantis Almaliotis, Eleni Papadopoulou, Leonidas Karamitopoulos, Fotios Topouzis, Vasileios Karampatakis; Analysis of central macular thickness in patients with dry Age related Macular Degenaration and cardiovascular risk factors. Invest. Ophthalmol. Vis. Sci. 2021;62(11):62.

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Abstract

Purpose : The aim of this study was to evaluate the central macular thickness (CMT) values in the eyes of patients with Dry age-related Macular Degeneration (AMD) in association with systematic hypertension, hyperlipidemia, diabetes mellitus, smoking status and family history.

Methods : Forty eight eyes of twenty nine subjects with dry AMD were included in the study. A comphrehensive medical report regarding systemic comorbidities were obtained and CMT was evaluated via spectral domain-optical coherence tomography (SD-OCT). Central retinal thickness values were compared among participants in order to indentify systemic factors that might be correlated. Comparisons of CMT values among patients with or without a risk factor were performed by applying t-test for independent samples. Statistical significance was set at 5% (p<0.05). Data were analyzed using IBM SPSS Statistics for Windows, version 25.0. (Armonk, NY: IBM Corp).

Results : The subjects with dry AMD (mean age: 80.60 years; SD= 8.06; 9 males, 20 females) had a mean best-corrected visual acuity (BCVA) of 0.75 logMAR. The mean time of AMD onset was 8.33, SD= 4.98. 86.2% (n=25) of patients had systemic hypertension, 69% (n=20) hyperlipidemia, 27.6% (n=8) diabetes mellitus and 58.6% (n=17) were smokers. Furthermore, 20.7% 9n=6) of patients had a family history of AMD. Mean CMT at right eyes and left eyes was 193.78 and 207.60, respectively. CMT (at both eyes) was significantly lower [t(46)=-2.182, p=.034] in patients with hypelipidemia . Specifically, in patients with hypelipidemia the Mean CMT at right and left eyes was found M=181.47, SD= 49.84 and M=198.06, SD=48.40, respectively versus M= 216.88, SD= 37.58 and M=224.56, SD= 48.88 respectively in patients without hyperlipidemia, as well.

Conclusions : This study demonstrated that hyperlipidemia might result in a remarkably thinner CMT. Furthermore, the mean CMT values at both eyes was found to be affected in all subjects with the vast majority of them having systematic comorbidities. These findings suggest that it may be necessary to consider the presence of hypertension hypelipidemia, diabetes mellitus, smoking status and family history when central macular thickness volume is evaluated.

This is a 2021 Imaging in the Eye Conference abstract.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2024 Association for Research in Vision and Ophthalmology.
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