This was a cross-sectional observational study of the difference between the morphology and hemodynamics of the OA in patients with ACS and healthy controls (HCs). The study protocol was approved by the local ethics committee of Beijing Friendship Hospital (2020-P2-008-01) and was conducted in accordance with the tenets of the Declaration of Helsinki, the International Conference on Harmonization Good Clinical Practice guidelines, and applicable Chinese laws. All participants provided written informed consent.
The medical records of all patients with ACS admitted to the Beijing Friendship Hospital from January 2020 to September 2020 who underwent CTA and those of healthy individuals who underwent CTA for other reasons were reviewed. All patients with ACS had a clear diagnosis and thus underwent coronary angiography. The hospital electronic medical records were verified, and parameters were collected and recorded. Each participant then underwent a detailed ocular examination, including Snellen best-corrected visual acuity, intraocular pressure (by non-contact tonometry), slit-lamp examination, fundus color photography, axial length measurement by optical biometry (IOL Master; Carl Zeiss Meditec, Jena, Germany), and optical coherence tomography (OCT; Heidelberg Engineering, Heidelberg, Germany). The exclusion criteria were as follows: (1) any existing eye refractive medium opacity, orbital space–occupying diseases, glaucoma, optic neuritis glaucoma, or other significant eye pathologies such as blindness and inability to fixate; (2) intracranial space-occupying lesions and fundus lesions caused by systemic diseases, such as diabetes and high blood pressure; and (3) active syphilis, hepatitis B, or other infectious diseases.