We performed linear regression analysis to identify the factors associated with the MD slope calculated from the whole preoperative to postoperative VFs (
Table 5). A younger age (
P = 0.001), larger axial length (
P = 0.019), worse preoperative MD of the VF (
P = 0.021), higher preoperative IOP (
P = 0.022), lower preoperative intradisc VD in the deep vascular layer (
P = 0.001), less change in the intradisc deep VD after surgery (
P < 0.001), and a larger preoperative FAZ area (
P = 0.096) were significant factors associated with the MD slope in the univariate analysis. Among these factors, worse preoperative MD of the VF (
P = 0.006), lower preoperative intradisc VD in the deep vascular layer (
P < 0.001), and less change in the intradisc deep VD after surgery (
P < 0.001) were significantly associated with the MD slope in the multivariate analysis. When regression analysis was separately performed with preoperative and postoperative MD slopes, a younger age (
P = 0.007) was significant factor associated with preoperative MD slope (
Table 6). A younger age (
P = 0.002), larger axial length (
P = 0.011), worse preoperative MD of the VF (
P = 0.036), higher preoperative IOP (
P = 0.030), and less change in the intradisc deep VD after surgery (
P = 0.022) were significant factors associated with the postoperative MD slope.