Investigative Ophthalmology & Visual Science Cover Image for Volume 63, Issue 7
June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Flicker ERG findings in posterior uveitis
Author Affiliations & Notes
  • Ngoc Than
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Hien Luong Doan
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Brandon Pham
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
    Ophthalmology, University of Miami Mary and Edward Norton Library of Ophthalmology, Miami, Florida, United States
  • Jaclyn Hwang
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Jonathan Regenold
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Moosa Zaidi
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Youan Hasan Khan
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Wataru Matsumiya
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • SungWho Park
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
    Ophthalmology, Pusan National University, Kumjeong-ku, Korea (the Republic of)
  • Hashem Ghoraba
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Christopher Or
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Gunay Uludag
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Azadeh Mobasserian
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Amir Akhavanrezayat
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Diana V Do
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Quan Dong Nguyen
    Ophthalmology, Stanford University School of Medicine, Stanford, California, United States
  • Footnotes
    Commercial Relationships   Ngoc Than None; Hien Doan None; Brandon Pham None; Jaclyn Hwang None; Jonathan Regenold None; Moosa Zaidi None; Youan Khan None; Wataru Matsumiya None; SungWho Park None; Hashem Ghoraba None; Christopher Or None; Gunay Uludag None; Azadeh Mobasserian None; Amir Akhavanrezayat None; Diana Do None; Quan Nguyen None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 386 – F0424. doi:
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      Ngoc Than, Hien Luong Doan, Brandon Pham, Jaclyn Hwang, Jonathan Regenold, Moosa Zaidi, Youan Hasan Khan, Wataru Matsumiya, SungWho Park, Hashem Ghoraba, Christopher Or, Gunay Uludag, Azadeh Mobasserian, Amir Akhavanrezayat, Diana V Do, Quan Dong Nguyen; Flicker ERG findings in posterior uveitis. Invest. Ophthalmol. Vis. Sci. 2022;63(7):386 – F0424.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Electroretinography (ERG), which measures the electrical activity of retinal photoreceptors, has been employed in the management of retinal diseases. Recently, a simplified flicker ERG system has been developed. This cross-sectional study explores whether the Diopsys® flicker ERG system can be used in the monitoring of posterior uveitis patients.

Methods : Patients with posterior uveitis from a single institution were included. Patients with concomitant retinal disease such as diabetic retinopathy or age-related macular degeneration were excluded. Demographic and clinical data, including flicker ERG (Diopsys® NOVA), were collected. Statistical analyses were performed with STATA 16.0 software, and the Student’s t-test was used to compare means of different groups.

Results : A total of 85 patients (134 eyes) were studied. Diagnoses included juvenile idiopathic arthritis associated uveitis, Birdshot, and Behçet’s disease among others. Mean age was 36.89 ± 18.06 years. Fifty-two eyes had retinal vasculitis and 62 eyes had optic disc inflammation. There was a statistically significant difference in magnitude between eyes with (n=52) and without (n=82) retinal vasculitis (p=0.02). In addition, eyes with diffuse (posterior and peripheral) vasculitis (n=13) had reduced magnitude compared to eyes with only peripheral vasculitis (n=39) (p<0.01). However, no significant difference was found between eyes with and without optic disc inflammation (p=0.08).

Conclusions : Based on the index study, the Diopsys® flicker ERG system may aid in the monitoring of eyes with posterior uveitis.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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