June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Exploring Reticular Pseudodrusen Extent and Impact on Cone-Mediated Visual Sensitivity in Intermediate Age-Related Macular Degeneration
Author Affiliations & Notes
  • Himeesh Kumar
    Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia
    Surgery (Ophthalmology), The University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, Australia
  • Robyn H Guymer
    Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia
    Surgery (Ophthalmology), The University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, Australia
  • Lauren AB Hodgson
    Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia
  • Xavier Hadoux
    Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia
  • Zhichao Wu
    Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia
    Surgery (Ophthalmology), The University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, Australia
  • Footnotes
    Commercial Relationships   Himeesh Kumar None; Robyn Guymer Roche, Code C (Consultant/Contractor), Genentech, Code C (Consultant/Contractor), Novartis, Code C (Consultant/Contractor), Bayer, Code C (Consultant/Contractor), Apellis, Code C (Consultant/Contractor); Lauren Hodgson None; Xavier Hadoux None; Zhichao Wu None
  • Footnotes
    Support  This work was supported by the National Health & Medical Research Council of Australia (grant APP1181010 [RHG, ZW] and fellowships GNT1103013 [RHG] and and 2008382 [ZW]) and a Macular Disease Foundation Australia grant (ZW, RHG).
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 328 – F0159. doi:
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      Himeesh Kumar, Robyn H Guymer, Lauren AB Hodgson, Xavier Hadoux, Zhichao Wu; Exploring Reticular Pseudodrusen Extent and Impact on Cone-Mediated Visual Sensitivity in Intermediate Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2022;63(7):328 – F0159.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To explore the impact of the extent of reticular pseudodrusen (RPD) on cone-mediated visual sensitivity in individuals with intermediate age-related macular degeneration (AMD).

Methods : 570 eyes from 285 participants with bilateral large drusen underwent microperimetry testing under mesopic conditions to assess the visual sensitivity of the central 3.6-mm region and multimodal imaging to determine the extent of RPD in the central 20ox20o region (at the eye level). Mean visual sensitivity within five sectors in the central 3.6-mm region sampled on microperimetry and the extent of RPD in these sectors, were derived. Linear mixed models were used to examine the association between the extent of RPD on (i) overall mean visual sensitivity, and (ii) sector-based mean sensitivity.

Results : An increasing extent of RPD at the eye level and within sectors were associated with a significant reduction in overall and sector-based mean sensitivity respectively (P<0.001 for both). However, when both RPD parameters were considered together in a multivariable model, only an increasing extent of RPD at the eye level (P<0.001), and not within each sector (P=0.178), was independently associated with reduced sector-based mean sensitivity.

Conclusions : Cone-mediated visual sensitivity is generally reduced in non-late AMD eyes with RPD compared to AMD eyes without RPD, with greater reductions with an increasing extent of RPD. However, reduced sector-based visual sensitivities are explained by the overall extent of RPD present, rather than their extent within the sector itself. These findings suggest that there are generalized pathogenic changes in eyes with RPD accounting for the observed cone-mediated visual dysfunction.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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