June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Relationship between Dry Eye and Myopia in Children
Author Affiliations & Notes
  • Kazuo Tsubota
    Tsubota Laboratory, Inc., Shinjuku-ku, Tokyo, Japan
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Debabrata Hazra
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Erisa Yotsukura
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Kiwako Mori
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Tomoki Maruyama
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Mamoru Ogawa
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Akiko Hanyuda
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Kazuno Negishi
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Hidemasa Torii
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Toshihide Kurihara
    Opthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
    Laboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Kazuo Tsubota Tsubota Laboratory, Inc., Code E (Employment), TissueTech, Inc., Tear Solutions, Cellusion, Inc., Tsubota Laboratory, Inc., RestoreVision, Code I (Personal Financial Interest); Debabrata Hazra None; Erisa Yotsukura None; Kiwako Mori None; Tomoki Maruyama None; Mamoru Ogawa None; Akiko Hanyuda None; Kazuno Negishi None; Hidemasa Torii None; Toshihide Kurihara None
  • Footnotes
    Support  The Japan Society for the Promotion of Science KAKENHI Grant Number 18K16934, 21K16881 and Takeda Science Foundation (Osaka, Japan).
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 249 – A0103. doi:
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    • Get Citation

      Kazuo Tsubota, Debabrata Hazra, Erisa Yotsukura, Kiwako Mori, Tomoki Maruyama, Mamoru Ogawa, Akiko Hanyuda, Kazuno Negishi, Hidemasa Torii, Toshihide Kurihara; Relationship between Dry Eye and Myopia in Children. Invest. Ophthalmol. Vis. Sci. 2022;63(7):249 – A0103.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the association between dry eye disease (DED) and myopia by evaluating higher order aberrations (HOAs) and choroidal thickness (CT) among myopic children with DED symptoms. The incidence of dry eye and myopia have increased dramatically in modern society. Is it a coincidence or related to the lifestyle in modern society?

Methods : In this cross-sectional study, we recruited 72 myopic (spherical equivalent of ≤ -0.5 diopter) children with DED symptoms (age, 12.8 ± 2.7 [mean ± standard deviation] years) who presented to Keio University Hospital Myopia Clinic. They were measured for the tear film breakup time (BUT), HOAs, CT, axial length (AL) and refraction. Lifestyle questionnaires were administered, and the correlations between the BUT and HOAs were evaluated. Multiple regression analyses were performed to identify relationships among myopia and BUT/lifestyle factors, myopia and corneal/intraocular/total ocular HOAs (spherical aberration [SA], 3rd-order [S3], 4th-order [S4] and the sum of the 3rd- to 6th-order aberrations [THOA] evaluated with a natural pupillary diameter [average value, φ = 6.1 mm]), CT and BUT/AL.

Results : The BUT, CT, AL, and cycloplegic refraction were 5.7 ± 3.1 seconds, 285.3 ± 38.4 μm, 25.52 ± 1.14 mm, and -4.61 ± 2.38 diopters, respectively. The BUT was correlated significantly with the corneal HOAs (SA, β = -0.323, P = 0.02; S4, β = -0.497, P < 0.001; THOA, β = -0.362, P = 0.009) and intraocular HOAs (S3, β = -0.299, P = 0.04; S4, β = -0.369, P = 0.008; THOA, β = -0.368, P = 0.009) but not with total ocular HOAs. Multiple regression analyses showed that the AL was associated significantly with the BUT (β = -0.067, P = 0.004) and the intraocular S3, intraocular THOA, total ocular S3, and total ocular THOA (β = -21.8, 21.2, -41.7, and 43.6, respectively; P = 0.02, 0.048, 0.045, and 0.049, respectively) but not with the corneal HOAs. The CT was associated significantly with the BUT and AL (β = 9.15 and -7.85, respectively; P < 0.001 and = 0.01, respectively).

Conclusions : We showed that the BUT was associated significantly with the CT that is related to the AL. As the parasympathetic nervous system affects the lacrimal glands and CT, the parasympathetic nervous system might be a common upstream factor in the association between DED and myopia.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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