Abstract
Purpose :
To assess the incidence of dysphotopsia symptoms in patients with priarmy angle-closure glaucoma and/or primary angle-closure suspect with various positions of laser peripheral iridotomies (LPI).
Methods :
The authors searched five electronic databases including CENTRAL, MEDLINE, EMBASE and trial registries for randomised controlled trials (RCTs). The search was last conducted on October 4, 2021. Language was not limited to English. Articles were excluded if LPI was compared to other interventions or if the measured outcome did not include dysphotopsia symptoms. Risk ratio was used for binary outcomes.
Results :
Five RCTs involving 2364 eyes of 1182 patients were included in the review. Four studies compared superior with nasal/temporal LPIs; one study compared superior with inferior LPIs. The main weakness was potential selection bias for two studies and the lack of blinding for investigative personnel. Risk of bias was assessed at the individual study and outcome level with GRADE approach vigorously applied. Moderate-certainty evidence shows no difference between superior and nasal/temporal LPIs. Low-certainty evidence demonstrated conflicting results.
Conclusions :
Various LPI positions used to reduce incidence of dysphotopsia symptoms have been studied. More high-certainty RCTs are needed as clinical decisions currently need to be made based on the available evidence.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.