Seasonal Variation of Intraocular Pressure in Non-Glaucomatous Subjects

Abstract

Purpose : To evaluate seasonal variation of intraocular pressure (IOP) in non-glaucomatous subjects from records established in two large databases since 1995 and 2005, i.e., the Kyoto Prefectural University of Medicine Glaucoma Registry (KPUM-GR) and the Kyoto Glaucoma Cohort Study (KGC), respectively, for the purpose of glaucoma genome research (i.e., data collected from both glaucoma patients and normal, healthy, non-glaucomatous, control-subject volunteers).

Methods : IOP data meeting the following inclusion criteria extracted from the KPUM-GR or KGC database was obtained: 1) subjects diagnosed as non-glaucomatous with bilateral visual fields within normal limits, 2) applanation (A) IOP (Haag-Streit) of ≤ 21mmHg, and 3) non-contact tonometry (N) (RKT-7700, Nidek) findings measured within 2 hours on the same day with A IOP. In all subjects, right-eye data was used for analysis. IOP seasonal variation was determined via regression-model analysis based on the mean values for each month for both A and N IOP by dividing the data into 12 groups by the month of measurement.

Results : Data-points extracted and later evaluated included 620 from the KPUM-GR and 868 independently derived from and KGC; i.e., a total of 1488 subjects [428 males, 1060 females, mean age: 62.2±11.5 (mean±SD) years]. The A IOP data revealed significant seasonal variation (P<0.01), i.e., lower IOP in summer and higher IOP in winter, and the N IOP data also showed significant seasonal variations.

Conclusions : The real-world data of the non-glaucomatous subjects in our two large databases revealed significant seasonal variation of IOP in both A and N.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.