Abstract
Purpose :
To evaluate the performance of two different white-light emitting diode (LED) confocal imaging systems in diabetic retinopathy (DR) grading.
Methods :
In this prospective, instrument validation study, participants with type 1 or type 2 diabetes were scanned consecutively with two different white LED confocal scanners: Eidon and DRSplus (Centervue, Padova, Italy). Two-field retinal photographs were captured for each eye using Eidon (60 degrees, macula-centred and disc-centred fields) and DRSplus (45 degrees, macula-centred and disc-centred fields). Retinal images were randomly submitted to a certified retinal expert for grading in accordance with the DR grading system used in the UK National Health service (NHS). All case were also graded as referable DR (RDR) or not RDR.
Results :
One hundred and fifty-five eyes of 78 diabetic patients were included in the analysis. Mean (± standard deviation) age of enrolled patients was 59.2 (± 5.3) years. Images from 5 eyes (3.2%) were classified as ungradable using DRSplus, 3 of these cases were judged as not gradable using Eidon. Among all gradable exams, the level of DR identified on images acquired using DRSplus agreed with those obtained with Eidon in 94% of cases. Cohen's kappa coefficient (κ) was 0.88. There was a 100% agreement when considering RDR.
Conclusions :
An excellent agreement between Eidon and DRSplus was reported in determining the DR severity and RDR.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.