June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Cross-Sectional Study Comparing Cone Function in Participants with Intermediate Age-Related Macular Degeneration (iAMD) and in Participants with iAMD and Non-Foveal Nascent Geographic Atrophy (nGA)
Author Affiliations & Notes
  • Karl G Csaky
    Retina Foundation of the Southwest, Dallas, Texas, United States
  • Footnotes
    Commercial Relationships   Karl Csaky Roche/Genentech, Abbvie/Allergan, Novartis, NGM Biopharmaceuticals, Johnson & Johnson, Allexion, Retrotope, Merck & Co., Code C (Consultant/Contractor)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 881. doi:
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    • Get Citation

      Karl G Csaky; Cross-Sectional Study Comparing Cone Function in Participants with Intermediate Age-Related Macular Degeneration (iAMD) and in Participants with iAMD and Non-Foveal Nascent Geographic Atrophy (nGA). Invest. Ophthalmol. Vis. Sci. 2022;63(7):881.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare cone function in participants with drusen only intermediate age-related macular degeneration (iAMD) and those with iAMD and non-foveal nascent geographic atrophy (nGA) to determine if a more advanced stage of iAMD has an effect on cone photoreceptors.

Methods : In this cross-sectional study, 60 eyes from 33 participants - 30 with drusen only (15 participants) and 30 (18 participants) with nGA determined by spectral-domain optical coherence tomography (OCT) underwent testing for visual acuity (VA), low-luminance visual acuity (LLVA), qCSF algorithm (area under log CSF (AULCSF) under both standard photopic (90 cd/m2) and low luminance (2.0 log neutral density filter)(LL AULCSF) conditions. Student’s t-test was used to compare differences in LLVA, AULCSF and LL AULCSF. Correlations between VA, AULCSF and LL AULCSF were determined using Pearsons’ r.

Results : In the iAMD group VA = 81 letters ± 3 (mean ± standard deviation), LLVA = 65 letters ± 4, AULCSF = 0.99 ± 0.0.5 and LL AULCSF = 0.38 ± 0.04 while in the nGA group VA = 77 letters ± 4, LLVA = 61 letters ± 8, AULCSF = 0.87 ± 23 and LL AULCSF = 0.28 ± 0.15. Student t-test demonstrated a significant difference in LL AULCSF (p= .048) but not in LLVA (p= .048) or AULCSF (p= .048). Correlation analysis demonstrated significant relationships between visual acuity and AULCSF in both iAMD and nGA groups (r = 0.83 (p<10-9); (r = 0.61 (p=0.0004) and between VA and LL AULCSF in the in the iAMD group (0.68 (p<10-5) but did not correlate with AULCSF under low luminance conditions (r = 2.9 (p= 0.13) in the nGA group.

Conclusions : Nascent GA may represent a more advanced form of iAMD that can impact preferentially one measure of low luminance = LL AULCSF. As normal vision does not correlate with this measurement this test should be considered for use in clinical trials of iAMD.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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