June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Trial study on applying focal macular electroretinogram function on the microperimetry system
Author Affiliations & Notes
  • Naoto Suzuki
    Mechanical Engineering, National Institute of Technology, Numazu College, Numazu, Shizuoka, Japan
  • Footnotes
    Commercial Relationships   Naoto Suzuki Japan Society for the Promotion of Science, Code F (Financial Support)
  • Footnotes
    Support  Grants‐in‐aid for Scientific Research (No. 18K12122) in Japan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 756 – F0408. doi:
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    • Get Citation

      Naoto Suzuki; Trial study on applying focal macular electroretinogram function on the microperimetry system. Invest. Ophthalmol. Vis. Sci. 2022;63(7):756 – F0408.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This study aims to investigate cryptogenic diseases including macular dystrophy. The decline in visual sensitivity of the retina has been measured using microperimetry, the retinal layer causing this decline has been identified using multifocal electroretinogram (ERG). Instead of the multifocal ERG, a focal macular ERG function has been applied on the microperimetry.

Methods : This apparatus is made of illumination and photographic optical systems separated by a mirror with a hole. Additionally, it is made of a microperimetry optical system and an ERG optical system separated by a cold mirror. The apparatus consists of an Edmund infrared camera EO-50231, a lens with a 25-mm focal length, a halogen lamp, an objective lens with a 50-mm focal length, four double convex lenses with a 100-mm focal length, two aperture stops, a mirror, a 45° cold mirror, a 12.1-inch high brightness monitor with 2,000 cd/m2, and an artificial eye. A differential amplifier with gain 10, high-pass filter with a 21.2-Hz cut-off frequency, 50-Hz notch filter, and two non-inverting amplifiers with gains 1001 and 11 have been deployed in this study. Moreover, this study used the National Instruments’ I/O device USB-6216, shielded connector block SCB-68A, the Nihon Kohden’s plate electrode NE-113A, the Nihon Kohden’s electromagnetic shield sheet Y049, and the LabVIEW 2018 software for data retrieval. To conduct the focal macular ERG, a DynaScan’s 49-inch ultrahigh brightness liquid crystal display (LCD) with 3,500 cd/m2 has been prepared. The focal macular ERG software was developed using C++ Builder 10.2.

Results : On the ultrahigh brightness LCD, the ERG software could show three sizes of stimulus spot circles: 5°, 10°, and 15° in diameters. Moreover, a function, which could adjust size of the stimulus spot circle, has been added as the diameter was changed from 1° to 15°.The stimulus spot circle could be shown as the circle’s center was similar to an examination target’s center of the microperimetry. The software showed a flicker stimulation as the frequency was changed from 10 Hz to 100 Hz.

Conclusions : The focal macular ERG function is expected to identify the retinal layer causing visual alterations at specific points throughout the retina. Further work towards preclinical animal testing and clinical evaluation are required.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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