June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Repeatability of electroretinogram measurements
Author Affiliations & Notes
  • Chi Mong Or
    Ophthalmology, Stanford University, Stanford, California, United States
  • Hashem Ghoraba
    Ophthalmology, Stanford University, Stanford, California, United States
  • Moosa Zaidi
    Ophthalmology, Stanford University, Stanford, California, United States
  • Amir Akhavanrezayat
    Ophthalmology, Stanford University, Stanford, California, United States
  • Jonathan Regenold
    Ophthalmology, Stanford University, Stanford, California, United States
  • Gunay Uludag
    Ophthalmology, Stanford University, Stanford, California, United States
  • Cigdem Yasar
    Ophthalmology, Stanford University, Stanford, California, United States
  • SungWho Park
    Ophthalmology, Stanford University, Stanford, California, United States
  • Ngoc Than
    Ophthalmology, Stanford University, Stanford, California, United States
  • Jaclyn Joyce Hwang
    Ophthalmology, Stanford University, Stanford, California, United States
  • Quan Dong Nguyen
    Ophthalmology, Stanford University, Stanford, California, United States
  • Footnotes
    Commercial Relationships   Chi Mong Or None; Hashem Ghoraba None; Moosa Zaidi None; Amir Akhavanrezayat None; Jonathan Regenold None; Gunay Uludag None; Cigdem Yasar None; SungWho Park None; Ngoc Than None; Jaclyn Hwang None; Quan Nguyen None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 740 – F0392. doi:
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    • Get Citation

      Chi Mong Or, Hashem Ghoraba, Moosa Zaidi, Amir Akhavanrezayat, Jonathan Regenold, Gunay Uludag, Cigdem Yasar, SungWho Park, Ngoc Than, Jaclyn Joyce Hwang, Quan Dong Nguyen; Repeatability of electroretinogram measurements. Invest. Ophthalmol. Vis. Sci. 2022;63(7):740 – F0392.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Electroretinography (ERG) plays a vital role in the diagnosis of various eye diseases. The International Society for Clinical Electrophysiology of Vision (ICSEV) has published guidelines standardizing the acquisition of ERG. However, repeatability of ERG measurements has not been clearly elucidated. In this study, we aim to assess the repeatability of ERG measurements as performed using ICSEV guidelines.

Methods : 98 consecutive patients with various ocular conditions and a recent ERG were included in our study. Full-field ERG (Diagnosys, LLC) was performed by a single examiner, with repeat measurements recorded as per ICSEV guidelines. The magnitudes of the A and B waves, along with their respective latencies, under each testing condition were collected. Statistical tests of repeatability including coefficient of variation and intraclass correlation coefficient (ICC) were employed. Statistical analysis was performed using MedCalc software.

Results : Using the coefficient of variation, A and B wave latencies and magnitudes had very good repeatability (<10) under the Scotopic 3 and 10 conditions. A wave latency, B wave latency and B wave magnitude measurements under Scotopic 0.01 conditions also had very good repeatability. A wave latency and B wave magnitude under both photopic conditions had good repeatability (10-20). A wave magnitude under both photopic conditions and the A wave magnitude under Scotopic 0.01 had poor repeatability (>30). Using the ICC, the scotopic 3 and 10 measurements had the best repeatability, with multiple measures demonstrating excellent repeatability. Measurements under scotopic 0.01 conditions also had good to excellent repeatability. The photopic measurements had varied repeatability scores, with the A wave magnitude and latency under photopic 3 conditions demonstrating poor reliability.

Conclusions : ERG measurements had variable repeatability using the standard protocol, with those under scotopic 3 and 10 conditions demonstrating the highest degree of repeatability. Further studies are required to elucidate this and explore the repeatability of ERG measurements in different patient populations.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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