June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Clock-hour Topography and Extent of the Photoreceptor and Retinal Pigment Epithelium Damages in Hydroxychloroquine Retinopathy: Functional Correlation and Implications for Classifications
Author Affiliations & Notes
  • Seong Joon Ahn
    Hanyang University, Seongdong-gu, Seoul, Korea (the Republic of)
  • Ko Eun Kim
    Ophthalmology, Asan Medical Center, Songpa-gu, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Seong Joon Ahn None; Ko Eun Kim None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 679 – F0133. doi:
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      Seong Joon Ahn, Ko Eun Kim; Clock-hour Topography and Extent of the Photoreceptor and Retinal Pigment Epithelium Damages in Hydroxychloroquine Retinopathy: Functional Correlation and Implications for Classifications. Invest. Ophthalmol. Vis. Sci. 2022;63(7):679 – F0133.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the clock-hour topographic characteristics on the photoreceptor and retinal pigment epithelium (RPE) damages and correlate them with functional defects in eyes with hydroxychloroquine retinopathy

Methods : Among 152 eyes diagnosed with hydroxychloroquine retinopathy, those with coexistent retinal or macular diseases or those with poor image quality of optical coherence tomography (OCT) and fundus autofluorescence (FAF) images were excluded. In total, 149 eyes of 75 patients were included for the analyses and classified into parafoveal, pericentral, and mixed retinopathy according to disease pattern and also into early, moderate, and severe ones. Clock-hour topographic characteristics (from the fovea) and extents of the photoreceptor and RPE defects were evaluated by reviewing the OCT images obtained by 12 radial scans and wide-field FAF. The extent (numbers of involved clock-hour areas) of photoreceptor and RPE damages was correlated with perimetric parameters such as mean deviation (MD), pattern standard deviation (PSD), and visual field indices (VFI).

Results : Whereas the photoreceptor damages were most commonly noted at the 6 o'clock area in both parafoveal and pericentral retinopathy, the RPE damages were most commonly noted at the nasal area, peripapillary ones, in pericentral eyes. The extent of RPE damages was almost identical between OCT and FAF imaging, whereas that of photoreceptor defects was significantly greater in OCT, indicating superior sensitivity of OCT for the detection of the photoreceptor damages. The extent of photoreceptor damages significantly correlated with MD and VFI (both P< 0.05) and this seemed to better reflect the functional defects in eyes with the retinopathy, as the disparity in the visual function between moderate and severe eyes and the variability of the perimetric parameters in the same severity (moderate or severe) could be explained by the disparity or differences in the extent.

Conclusions : This study showed clock-hour topographic characteristics and extents of the photoreceptor and RPE damages in eyes with hydroxychloroquine retinopathy. From the significant correlation between the extent of photoreceptor damages and perimetric parameters, the information may be utilized for functional correlation and classification of hydroxychloroquine retinopathy.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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