Abstract
Purpose :
To investigate agreement of glaucoma progression diagnosis between optic disc and macula by regression analysis of retinal structures measured with spectral-domain optical coherence tomography (SD-OCT) in a prospective observational cohort study.
Methods :
Primary open angle glaucoma patients with visual field defect above -18dB of mean deviation value were included in this prospective study. Exclusion criteria were eyes with ocular diseases including cataract, abnormality history of intraocular surgery except successful glaucoma surgery, and the onset of other ocular diseases during study period that may influence the SD-OCT measurement. The circum-papillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell complex (GCC) thickness were measured using SD-OCT (NIDEK RS-3000 Advance) during three years with arbitrary intervals less than six months. Linear regression analysis of cpRNFL thicknesses in temporal, superior, nasal and inferior quadrants and GCC thicknesses in superior macula and inferior macula were performed with build-in software of the SD-OCT. A statistically significant thinnings in any area were defined as glaucoma progression (P < 0.05).
Results :
48 eyes of 48 glaucoma patients were included. Age and mean deviation at baseline visit were 61 ± 8.7 (mean ± standard deviation) years old and -5.7 ± 4.8dB. cpRNFL thinning rates (thickness at baseline) in temporal, superior, nasal and inferior quadrants were -0.38 ± 1.21 μm/y (57.9 ± 17.5 μm) , –1.49 ± 2.07 μm/y (90.3 ± 21.2 μm), 0.0 ± 1.4 μm/y (74.3 ± 14.4 μm) and -0.21 ± 1.63 μm/y (.2 ± 27.8 μm), respectively. GCC thinning rates (thickness at baseline) in suprerior and inferior macula were -0.18 ± 0.84 μm/y (84.6 ± 11.8 μm) and -0.07 ± 0.83 μm/y (74.7 ± 15.5 μm). Twenty four and 17 eyes were diagnosed as glaucoma progression by by cpRNFL and GCC, respectively, those were overlapped in 11 eyes. Kappa value was 0.21.
Conclusions :
Agreement of glaucoma progression diagnosis was fair between cpRNFL thinning and macular GCC thinning.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.