June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Pointwise correlations between different intraretinal layer thicknesses and retinal sensitivity as assessed by OCT and microperimetry in healthy and glaucomatous eyes
Author Affiliations & Notes
  • Jose Javier Garcia-Medina
    Hospital General Universitario Jose M Morales Meseguer, Murcia, Murcia, Spain
  • Lorena Lopez-Canovas
    Hospital General Universitario Reina Sofia, Murcia, Murcia, Spain
  • Vicente Zanon-Moreno
    European University of Valencia, Valencia, Valencia, Spain
  • Maria D Pinazo-Duran
    Universitat de Valencia, Valencia, Comunitat Valenciana, Spain
  • Monica Del-Rio-Vellosillo
    Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
  • Footnotes
    Commercial Relationships   Jose Javier Garcia-Medina None; Lorena Lopez-Canovas None; Vicente Zanon-Moreno None; Maria Pinazo-Duran None; Monica Del-Rio-Vellosillo None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 637 – A0377. doi:
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      Jose Javier Garcia-Medina, Lorena Lopez-Canovas, Vicente Zanon-Moreno, Maria D Pinazo-Duran, Monica Del-Rio-Vellosillo; Pointwise correlations between different intraretinal layer thicknesses and retinal sensitivity as assessed by OCT and microperimetry in healthy and glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 2022;63(7):637 – A0377.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the pointwise relationship between macular function and structure in healthy and glaucomatous eyes for inner and outer segmentations assessed by OCT.

Methods : 72 eyes were included and divided into two groups: control group made up of 27 eyes and a primary open-angle glaucoma (POAG) group of 45 eyes. All eyes underwent retinal sensitivity assessment with microperimetry MP-1 and the structure was studied with OCT (Spectralis). The following automatic segmentations were considered: outer retinal layer, ganglion cell layer (GCL), inner plexiform layer (IPL), GCL+IPL and ganglion cell complex (mRNGL+GCL+IPL). Microperimetry maps were exactly superimposed over OCT maps considering anatomical references by using Overlay2 software. Punctual thicknesses for each considered segmentation were obtained in correspondence with every point of assessed macular sensitivity. The displacement of the ganglion cells of the retina were considered for inner retinal segmentations. Structure-function associations were calculated by using Spearman correlation. Significant correlation maps were plotted.

Results : Healthy group did not show significant correlations in any of the considered segmentations. In contrast, we found positive significant correlations for inner retinal layers but not for outer retinal layer. This significant correlations followed different patterns: peripheral for mRNFL, paracentral in temporal area for GCL, IPL and GCL+IPL and combined for mRNGL+GCL+IPL. The highest number of significant correlations were obtained for mRNGL+GCL+IPL.

Conclusions : There are specific patterns of significant pointwise structure-function correlation in macula for inner retinal layers in POAG.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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