June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Combined Effects of Vessel Density and Intraocular Pressure on Retinal Ganglion Cell Function and Structure in Normal Tension Glaucoma Suspects with Obstructive Sleep Apnea
Author Affiliations & Notes
  • Vasiliki Gliagias
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
  • Andrew Tirsi
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
    Manhattan Eye Ear and Throat Institute, New York, New York, United States
  • Hosam Sheha
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
    Manhattan Eye Ear and Throat Institute, New York, New York, United States
  • Corey Ross Lacher
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
  • Derek Orshan
    New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, United States
  • Joby Tsai
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
  • Rohun Gupta
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
  • Stephen A Obstbaum
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
    Manhattan Eye Ear and Throat Institute, New York, New York, United States
  • Celso Tello
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
    Manhattan Eye Ear and Throat Institute, New York, New York, United States
  • Footnotes
    Commercial Relationships   Vasiliki Gliagias None; Andrew Tirsi Diopsys, Inc., Code C (Consultant/Contractor); Hosam Sheha None; Corey Lacher None; Derek Orshan None; Joby Tsai None; Rohun Gupta None; Stephen Obstbaum None; Celso Tello Diopsys, Inc., Code C (Consultant/Contractor)
  • Footnotes
    Support  Diopsys Inc.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 632 – A0372. doi:
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      Vasiliki Gliagias, Andrew Tirsi, Hosam Sheha, Corey Ross Lacher, Derek Orshan, Joby Tsai, Rohun Gupta, Stephen A Obstbaum, Celso Tello; Combined Effects of Vessel Density and Intraocular Pressure on Retinal Ganglion Cell Function and Structure in Normal Tension Glaucoma Suspects with Obstructive Sleep Apnea. Invest. Ophthalmol. Vis. Sci. 2022;63(7):632 – A0372.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Vascular factors have been shown to be responsible in the pathogenesis of Normal Tension Glaucoma (NTG). This cross-sectional study examined the ability of vessel density (VD) to predict variance across pattern electroretinogram (PERG) parameters, average retinal nerve fiber layer thickness (avRNFLT) and average ganglion cell-inner plexiform layer thickness (avGCL + IPLT) in NTG suspects with Obstructive Sleep Apnea (OSA).

Methods : Four pre-perimetric glaucoma subjects (7 eyes) with normal Humphrey 24-2 visual field tests, normal intraocular pressure (IOP) levels and suspicious optic nerve head were consecutively recruited at Manhattan Eye, Ear and Throat Hospital. Participants underwent Diopsys NOVA PERG and Cirrus Optical Coherence Tomography tests. Patients with documented OSA diagnosis were included. After controlling for Age (Step 1), hierarchical multiple linear regression analysis was used to determine the ability of IOP (Step 2) and VD (Step 3) to predict variance in dependent variables (Magnitude [Mag], MagnitudeD [MagD], MagnitudeD/Magnitude ratio [MagD/Mag ratio], avRNFLT and avGCL+IPLT).

Results : In prediction of Mag and MagD, after controlling for Age, VD explained 70.1% and 72.8% of variance (B= 0.149 [95% CI: 0.037, 0.262], p=0.024) (B= 0.134 [95% CI: 0.031, 0.237], p=0.026), respectively. IOP was not significant. In the prediction of MagD/Mag ratio, Age and IOP explained 62.3% and 29.3% of variance (B= 0.003 [95% CI: 0.000, 0.006], p=0.035) (B= 0.008 [95% CI: 0.002, 0.014], p=0.020), respectively. VD was not significant.
In prediction of avRNFLT, after controlling for Age, IOP and VD explained 76.9% and 11.0% of variance (B= -2.730 [95% CI: -4.316, -1.143], p=0.009) (B= 0.652 [95% CI: 0.079, 1.225], p=0.036), respectively.
In prediction of avGCL+IPLT, after controlling for Age, IOP and VD explained 69.3% and 6.00% of variance (B= -1.466 [95% CI: -2.115, -0.816], p=0.003) (B=-0.274 [95% CI:-0.480, -0.068], p=0.024), respectively.

Conclusions : In NTG suspects with OSA, VD was a significant predictor for Mag and MagD, demonstrating the importance of healthy microvasculature for normal retinal ganglion cell function. We report combined effects of VD and IOP on avRNFLT and avGCL+IPLT, emphasizing the need to further investigate this relationship, IOP diurnal fluctuations and IOP nocturnal elevations in OSA.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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