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Jing Hou, Kiwako Mori, Shin-ichi Ikeda, Heonuk Jeong, Hidemasa Torii, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota; Ginkgo biloba Extracts Showed Myopia Suppressive Effects in a Lens-Induced Myopia Model in Mice. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1452 – F0410.
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© ARVO (1962-2015); The Authors (2016-present)
Screening of food materials for myopia suppressive factors measuring expression of early growth response 1 (Egr-1), a myopia suppressive gene, demonstrated that ginkgo biloba extracts (GBEs) increase Egr-1 activity in a previous study. This study was aimed to assess the suppressive effects of GBEs on myopia using a lens-induced myopia model in mice.
3-week-old male C57B6/ J mice were randomly assigned to three groups: mice fed with normal chow and equipped with 0 diopter (D) lenses to their both eyes (control group), mice fed with normal chow and equipped with -30 D lenses to their both eyes (myopia-induced group), and mice fed with 0.0667% GBEs and equipped with -30 D lenses to their both eyes (GBEs group) (n = 8 in each group). Refraction, axial length, and choroidal thickness were measured with an infrared photorefractor and an SD-OCT system before and 3 weeks after feeding.
Compared with the control group, refraction (p < 0.001), axial length (p < 0.05), and choroidal thickness (p < 0.001) showed myopic shifts in the myopia-induced group three weeks after normal feeding. In the GBEs group, change in refraction was significantly suppressed compared with the myopia-induced group (-1.59 ± 3.90 D vs. -9.92 ± 2.49 D, p < 0.001). Change in axial length was significantly suppressed compared with the myopia-induced group (0.19 ± 0.04 mm vs. 0.22 ± 0.02 mm, p<0.05). Change in choroidal thickness in the GBEs group was significantly suppressed compared with the myopia-induced group (-0.27 ± 0.47 um vs. -1.32 ± 0.56 um, p < 0.01).
GBEs showed suppressive effects on myopia in mice.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.
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