June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Association of pattern electroretinogram parameters with structural and functional metrics in glaucoma
Author Affiliations & Notes
  • Asmaa Youssif
    Duke University, Durham, North Carolina, United States
    Assiut University Faculty of Medicine, Assiut, Egypt
  • Tais Estrela
    Duke University, Durham, North Carolina, United States
  • Alessandro A. Jammal
    Duke University, Durham, North Carolina, United States
  • Rizul Naithani
    Duke University, Durham, North Carolina, United States
  • Ndidi-Amaka Onyekaba
    Duke University, Durham, North Carolina, United States
  • Felipe Medeiros
    Duke University, Durham, North Carolina, United States
    Electrical and Computer Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, United States
  • Footnotes
    Commercial Relationships   Asmaa Youssif None; Tais Estrela None; Alessandro A. Jammal None; Rizul Naithani None; Ndidi-Amaka Onyekaba None; Felipe Medeiros Aerie Pharmaceuticals, Allergan, Annexon, Biogen, Carl Zeiss Meditec, Galimedix, IDx, Stealth Biotherapeutics, Reichert, Code C (Consultant/Contractor), Allergan, Carl Zeiss Meditec, Google Inc, Heidelberg Engineering, Novartis, Reichert, Code F (Financial Support), nGoggle Inc, Code P (Patent)
  • Footnotes
    Support  Egyptian government 1 year scholarship grant for PhD thesis on OCTA, 2019-2020, National Institute of Health/National Eye Institute grant EY029885 and EY031898 (FAM).
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1280 – A0420. doi:
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      Asmaa Youssif, Tais Estrela, Alessandro A. Jammal, Rizul Naithani, Ndidi-Amaka Onyekaba, Felipe Medeiros; Association of pattern electroretinogram parameters with structural and functional metrics in glaucoma. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1280 – A0420.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the association of steady-state pattern electroretinogram (PERG) with standard automated perimetry (SAP) and optical coherence tomography (OCT) parameters in glaucoma.

Methods : This was a cross-sectional evaluation of glaucoma patients and normal controls included in an observational cohort study. Each patient underwent 24-2 SAP, OCT, and PERG testing with the Diopsys NOVA PERG contrast sensitivity protocol (ConSen protocol) within 7 days. The following PERG parameters were analyzed: MagnitudeD, corresponding to the amplitude of the average signal, and MagD/Mag Ratio, the consistency of the response. For both parameters, lower values indicate an increased likelihood of visual dysfunction. The parameters were tested at high (Hc) and low contrast (Lc). Tests with excessive artifacts or low signal quality were excluded. Linear mixed models nested at the patient and eye levels were used to evaluate the relationship between PERG parameters with SAP MD and RNFL thickness and R2 was used to measure the strength of the relationship.

Results : The study included 85 visits of 77 eyes of 40 subjects with mean age of 67.5±9.4 years. Eyes had an average SAP MD of -4.97±6.49dB and RNFL thickness of 74.1±18.0μm, with 18% of eyes classified as normal and 82% as glaucoma. The Lc MagnitudeD was 0.014 lower for each 1 MD dB lower (R2 =0.41; P = 0.001) and 0.040 lower for each 10 μm thinner RNFL (R2=0.38; P = 0.011), after adjustment for age and gender. For MagD/Mag ratio, RNFL thickness, but not SAP MD, was significantly associated with MagD/Mag ratio at Lc, with 0.03 lower value for each 10μm thinner RNFL (R2 = 0.39; P = 0.021). Neither RNFL nor SAP MD were significantly associated with PERG Hc parameters in multivariable analyses.

Conclusions : Low contrast stead-state PERG parameters were significantly associated with structural and functional metrics in glaucoma.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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