June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements
Liang Wang; Yingying Shi; Jonathan Russell; Mengxi Shen; Xiaoshuang Jiang; Prashanth G Iyer; Sonia H Yoo; Terri Rose; Rabash Georgia Habash; Guillermo Amescua; William J Feuer; Giovanni Gregori; Philip J Rosenfeld
Author Affiliations & Notes
  • Liang Wang
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Yingying Shi
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Jonathan Russell
    Institute for Vision Research and Department of Ophthalmology and Visual Sciences, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, United States
  • Mengxi Shen
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Xiaoshuang Jiang
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Prashanth G Iyer
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Sonia H Yoo
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Terri Rose
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Rabash Georgia Habash
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Guillermo Amescua
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • William J Feuer
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Giovanni Gregori
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Philip J Rosenfeld
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Liang Wang None; Yingying Shi None; Jonathan Russell Carl Zeiss Meditec, Code C (Consultant/Contractor); Mengxi Shen None; Xiaoshuang Jiang None; Prashanth Iyer None; Sonia Yoo None; Terri Rose None; Rabash Habash Carl Zeiss Meditec, Code C (Consultant/Contractor); Guillermo Amescua None; William Feuer None; Giovanni Gregori Carl Zeiss Meditec, Code F (Financial Support); Philip Rosenfeld Carl Zeiss Meditec, Code C (Consultant/Contractor), Carl Zeiss Meditec, Code F (Financial Support)
  • Footnotes
    Support  Research supported by grants from the Salah Foundation, an unrestricted grant from the Research to Prevent Blindness, Inc. (New York, NY), and the National Eye Institute Center Core Grant (P30EY014801) to the Department of Ophthalmology, University of Miami Miller School of Medicine. The funding organizations had no role in the design or conduct of the present research.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1045 – F0292. doi:
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      Liang Wang, Yingying Shi, Jonathan Russell, Mengxi Shen, Xiaoshuang Jiang, Prashanth G Iyer, Sonia H Yoo, Terri Rose, Rabash Georgia Habash, Guillermo Amescua, William J Feuer, Giovanni Gregori, Philip J Rosenfeld; Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1045 – F0292.

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Abstract

Purpose : The impact of cataract surgery on low luminance visual acuity deficit (LLVAD) measurements was investigated by comparing LLVAD measurements before and after cataract surgery.

Methods : Both normal luminance best-corrected visual acuity (NL-BCVA) and low luminance BCVA (LL-BCVA) were obtained using the Early Treatment Diabetic Retinopathy Study (ETDRS) charts. LL-BCVA was measured by using a 2.0-log unit neutral density filter in front of the examined eye (Wratten filter; Kodak, Rochester, NY). LLVAD scores were calculated by subtracting the LL-BCVA letter score from the NL-BCVA letter score. To estimate the test-retest variability of these visual acuity measurements, we used data from a previously published study entitled Complement Inhibition with Eculizumab for the Treatment of Nonexudative Age-Related Macular Degeneration (COMPLETE) Study, where the NL-BCVA, LL-BCVA, and LLVAD measurements were obtained at an interval of three months. In the current study, the impact of cataract surgery on LLVAD measurements was analyzed by comparing the NL-BCVA, LL-BCVA, and LLVAD measurements before and after cataract surgery.

Results : In the COMPLETE study, a total of 37 eyes were included at baseline and at the month-3 follow-up visit. There were no clinically significant differences in the NL-BCVA, LL-BCVA, and LLVAD measurements between baseline and the month-3 follow-up visits with mean differences in ETDRS letter scores of -1.1 (P=0.02), -1.3 (P=0.11), and 0.1 (P=0.88). In the current study, a total of 25 eyes were assessed before and after cataract surgery. Not surprisingly, there were significant increases in the NL-BCVA (+7.3) and LL-BCVA (+10.2) letter score measurements after cataract surgery (both P < 0.001); however, a statistically significant decrease in the average LLVAD measurement (-3.0) was observed after cataract surgery (P = 0.002). This change was due to the greater impact of cataracts on LL-BCVA measurements compared to the NL-BCVA measurements.

Conclusions : A greater effect of cataracts on LL-BCVA than NL-BCVA measurements caused a significant change in LLVAD values after cataract surgery. Caution should be exercised when using LLVAD measurements as a predictor of disease progression in phakic eyes with age-related macular degeneration.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Attribution-NonCommercial-NoDerivatives
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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