June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Multimodal Imaging Evaluation of Age-Related Macular Degeneration (AMD) in the AMD Ryan Initiative Study (ARIS)
Author Affiliations & Notes
  • Andrew Dieu
    Wisconsin Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Cynthia Hurtenbach
    Wisconsin Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Jeong W Pak
    Wisconsin Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Tiarnan D L Keenan
    National Eye Institute, Bethesda, Maryland, United States
  • Frederick L Ferris
    Ophthalmic Research Consultants, Waxhaw, North Carolina, United States
  • Charles P Wilkinson
    Johns Hopkins University, Baltimore, Maryland, United States
  • Christine Orndahl
    The Emmes Company LLC, Rockville, Maryland, United States
  • Traci E Clemons
    The Emmes Company LLC, Rockville, Maryland, United States
  • Emily Y Chew
    National Eye Institute, Bethesda, Maryland, United States
  • Amitha Domalpally
    Wisconsin Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States
  • Footnotes
    Commercial Relationships   Andrew Dieu None; Cynthia Hurtenbach None; Jeong Pak None; Tiarnan Keenan None; Frederick Ferris None; Charles Wilkinson None; Christine Orndahl None; Traci Clemons None; Emily Chew None; Amitha Domalpally None
  • Footnotes
    Support  P30 EY016665
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1028 – F0275. doi:
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      Andrew Dieu, Cynthia Hurtenbach, Jeong W Pak, Tiarnan D L Keenan, Frederick L Ferris, Charles P Wilkinson, Christine Orndahl, Traci E Clemons, Emily Y Chew, Amitha Domalpally; Multimodal Imaging Evaluation of Age-Related Macular Degeneration (AMD) in the AMD Ryan Initiative Study (ARIS). Invest. Ophthalmol. Vis. Sci. 2022;63(7):1028 – F0275.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : ARIS is a 5-year, multicenter, international, prospective, observational cohort study of participants with early AMD or reticular pseudodrusen (RPD) to identify novel biomarkers of disease progression. The purpose of this abstract is to describe the detailed imaging characteristics of the initially enrolled participants.

Methods : Baseline and 12-month follow up images were evaluated for four cohorts: early AMD, RPD only, RPD and large drusen, and healthy controls. Optical coherence tomography (OCT) images were graded for drusen structure and RPD characteristics. Fundus autofluorescence (FAF) images were graded for hypo and hyperautofluorescence and background pattern. Color fundus photography (CFP) images were graded for drusen size and area, pigmentary changes, RPD, and AMD severity scale.

Results : The cohorts comprised 38 eyes with early AMD, 18 eyes with RPD only, 10 eyes with RPD and large drusen, and 36 healthy control eyes.
In baseline evaluation of the early AMD cohort, OCT showed that drusen were predominantly dome shaped (52.8%) with hyperreflective cores (66.7%). Confluent drusen were observed in 47.2% of eyes. Abnormal FAF was seen in 50% of eyes in this cohort, all with areas of abnormality less than 2 disc areas. There was no significant hypo or hyper FAF in any eyes. CFP findings showed predominantly medium drusen (92.1%) and increased pigmentation in 5.3%. There were no eyes with depigmentation. Baseline AMD severity scale was level 2–4 in 63.2% of eyes. Progression of ≥ 1 step on the AMD scale over 12 months was seen in 17 (44.7%) eyes in the early AMD cohort.
Baseline assessment of the combined RPD cohorts showed global RPD distribution in 88.9% of eyes and superior distribution in 7.4%. Peripapillary RPD was seen in 25.9%. OCT-based staging showed stage 4 RPD in 63%. Baseline AMD scale was level 6 in 32.1% eyes and level 7 in 42.9%. Progression of ≥ 1 steps on the AMD scale over 12 months was seen in 2 (7.1%) eyes in the RPD cohort, with one eye progressing to late AMD. In the RPD subset with large drusen, drusen area ≥ 1 disc area was seen in 70% of eyes at baseline, with no eyes progressing ≥ 1 step on the AMD severity scale.

Conclusions : The 5-year ARIS introduces reproducible methods for detailed documentation of AMD phenotypes. This systematic evaluation will offer insight into the development of outcome variables in future studies of potential AMD treatments.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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