June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Tracking of fibrosis growth in neovascular age related macular degeneration
Author Affiliations & Notes
  • Markus Schranz
    University Clinic for Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Philipp Ken Roberts
    University Clinic for Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Alice Regina Motschi
    Medical Physics and Biomedical Engineering, Medizinische Universitat Wien, Wien, Wien, Austria
  • Marlene Hollaus
    University Clinic for Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Georgios Mylonas
    University Clinic for Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Stefan Sacu
    University Clinic for Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Michael Pircher
    Medical Physics and Biomedical Engineering, Medizinische Universitat Wien, Wien, Wien, Austria
  • Christoph K Hitzenberger
    Medical Physics and Biomedical Engineering, Medizinische Universitat Wien, Wien, Wien, Austria
  • Ursula Schmidt-Erfurth
    University Clinic for Ophthalmology and Optometry, Medizinische Universitat Wien, Wien, Wien, Austria
  • Footnotes
    Commercial Relationships   Markus Schranz None; Philipp Roberts None; Alice Motschi None; Marlene Hollaus None; Georgios Mylonas None; Stefan Sacu None; Michael Pircher None; Christoph Hitzenberger None; Ursula Schmidt-Erfurth None
  • Footnotes
    Support  Austrian Science Fund (FWF) KLI749-B
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1025 – F0272. doi:
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      Markus Schranz, Philipp Ken Roberts, Alice Regina Motschi, Marlene Hollaus, Georgios Mylonas, Stefan Sacu, Michael Pircher, Christoph K Hitzenberger, Ursula Schmidt-Erfurth; Tracking of fibrosis growth in neovascular age related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1025 – F0272.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To track retinal fibrosis (RF) growth in a group of treatment naïve eyes with neovascular age related macular degeneration (nAMD) over a follow up period of one year using a polarization sensitive optical coherence tomography prototype (PS-OCT).

Methods : In this prospective observational study, patients with treatment naïve nAMD were included and treated according to a treat and extend regimen with intravitreal aflibercept.
At baseline and month 12 each patient underwent
PS-OCT & color fundus photography (CFP) imaging.
PS-OCT technology depicts retinal fibrosis based on its birefringence, where fibrotic lesions appear as columns of uniform axis-orientation.
A new algorithm was used to automatically detect retinal fibrosis in single B-scans and subsequently calculate the area of the fibrosis within the image.

Results : We analyzed 54 eyes with treatment naïve MNV due to AMD.
The mean age was 76.9 years, 62.5% of patients were diagnosed with type 1, 20.83% with type 2 and 16.67 with type 3 MNV, respectively.
At baseline only 1 eye showed retinal fibrosis, in this eye fibrosis size increased from 2.4mm2 to 3.1 mm2 (increase by 30%).
At year 1, fibrotic tissue was detected in 5 more eyes, within those eyes
mean fibrosis area increased significantly from 0 to 4.51 ± 1.15mm2 (p<0.05).
Four out of 6 eyes with fibrosis were diagnosed with type 2 MNV.

Conclusions : In our study cohort around 10% of patients developed retinal fibrosis within one year.
Retinal fibrosis occurred more likely in type 2 MNV than in different MNV types.
This PS-OCT prototype combined with the new algorithm offers a precise and objective method to detect, measure and track fibrosis growth in nAMD.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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