June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
The APOE E4 allele is associated with faster rates of mGCIPL thinning in the PROGRESSA cohort
Sean Mullany; Henry Marshall; Emmanuelle Souzeau; Mark Hassall; Ashish Agar; Anna Galanopoulos; John Landers; Paul Mitchell; Paul Healey; Stuart L Graham; Alex W Hewitt; Stuart MacGregor; Puya Gharahkhani; Robert Casson; Owen Siggs; Jamie E Craig
Author Affiliations & Notes
  • Sean Mullany
    Ophthalmology, Flinders University, Adelaide, South Australia, Australia
  • Henry Marshall
    Ophthalmology, Flinders University, Adelaide, South Australia, Australia
  • Emmanuelle Souzeau
    Ophthalmology, Flinders University, Adelaide, South Australia, Australia
  • Mark Hassall
    Ophthalmology, Flinders University, Adelaide, South Australia, Australia
  • Ashish Agar
    Department of Ophthalmology, University of New South Wales, Sydney, New South Wales, Australia
  • Anna Galanopoulos
    Discipline of Ophthalmology and Visual Sciences, The University of Adelaide, Adelaide, South Australia, Australia
  • John Landers
    Ophthalmology, Flinders University, Adelaide, South Australia, Australia
  • Paul Mitchell
    Centre for Vision Research, University of Sydney - Camperdown and Darlington Campus Burkitt-Ford Library, Sydney, New South Wales, Australia
  • Paul Healey
    Centre for Vision Research, University of Sydney - Camperdown and Darlington Campus Burkitt-Ford Library, Sydney, New South Wales, Australia
  • Stuart L Graham
    Faculty of Health and Medical Sciences, Macquarie University, Sydney, New South Wales, Australia
  • Alex W Hewitt
    Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
  • Stuart MacGregor
    QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
  • Puya Gharahkhani
    QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
  • Robert Casson
    Discipline of Ophthalmology and Visual Sciences, The University of Adelaide, Adelaide, South Australia, Australia
  • Owen Siggs
    Ophthalmology, Flinders University, Adelaide, South Australia, Australia
    Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
  • Jamie E Craig
    Ophthalmology, Flinders University, Adelaide, South Australia, Australia
  • Footnotes
    Commercial Relationships   Sean Mullany None; Henry Marshall None; Emmanuelle Souzeau None; Mark Hassall None; Ashish Agar None; Anna Galanopoulos None; John Landers None; Paul Mitchell None; Paul Healey None; Stuart Graham None; Alex Hewitt None; Stuart MacGregor None; Puya Gharahkhani None; Robert Casson None; Owen Siggs None; Jamie Craig None
  • Footnotes
    Support  NHMRC program grant APP1150144, and project grant APP1157571
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1658 – A0153. doi:
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      Sean Mullany, Henry Marshall, Emmanuelle Souzeau, Mark Hassall, Ashish Agar, Anna Galanopoulos, John Landers, Paul Mitchell, Paul Healey, Stuart L Graham, Alex W Hewitt, Stuart MacGregor, Puya Gharahkhani, Robert Casson, Owen Siggs, Jamie E Craig; The APOE E4 allele is associated with faster rates of mGCIPL thinning in the PROGRESSA cohort. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1658 – A0153.

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Abstract

Purpose : This study sought to investigate the association between the apolipoprotein E (APOE) E4 allele and longitudinal retinal thinning in the ‘Progression Risk Of Glaucoma: RElevant SNPs with Significant Association’ (PROGRESSA) cohort, a prospective study of suspect and early manifest glaucoma.

Methods : Apolipoprotein E alleles and genotypes were determined in PROGRESSA, and an age- and ancestrally-matched normative cohort, the Blue Mountains Eye Study (BMES). Structural parameters of neuroretinal atrophy measured using spectral-domain optical coherence tomography (SD-OCT) including the macular ganglion cell complex (mGCIPL) and peripapillary retinal nerve fibre layer (pRNFL) were compared within the PROGRESSA cohort on the basis of genotype and presence of APOE E4 allele.

Results : Prospective rates of mGCIPL thinning were faster in participants harbouring at least one copy of the APOE E4 allele (beta coefficient=-0.13μm/year; p=3.6x10-4). These participants also had a thinner average mGCIPL (70.9μm vs. 71.9μm; p=0.011) and pRNFL (77.6μm vs. 79.2μm; p=0.045) after a minimum of three years of longitudinal follow-up.

Conclusions : The APOE E4 allele was associated with faster rates of average mCGIPL thinning and a thinner average pRNFL, suggesting that the APOE E4 allele is a risk factor for retinal ganglion cell degeneration.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Attribution-NonCommercial-NoDerivatives
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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