Abstract
Purpose :
There is limited data available for the Canadian adult population diagnosed with anti-MOG. The goal of this study was to increase the understanding of the ophthalmic and neurological manifestations of anti-MOG disease in adults living in a Canadian setting through a retrospective/prospective chart review. With more information on the disease, clinicians can better identify these patients, understand the disease progression, and manage treatment options.
Methods :
Data from standard of care ophthalmic and neurological assessments was collected over a 1-year period for patients who were diagnosed with Anti-MOG disease. Data collected includes patient demographics, ophthalmic assessment, neurological assessment, MRI and bloodwork results.
Correlation analysis was made between titer of MOG antibody and objective quantified ophthalmic findings, including electro-diagnostic results, MRI imaging, OCT imaging, and ophthalmic and neurological examination results.
Results :
Five patients who were diagnosed with Anti-MOG have been tested. Of these, 60% were female and 40% were male, with ages ranging from 18 to 63 years old. On ocular examination the majority of eyes had normal visual acuity (60%). The remaining eyes had, 20/30, 20/50, hand motion and light perception vision (one eye each, 3 patients). On fundus examination, half the eyes showed signs of optic atrophy on RNFL testing. Vision loss was asymmetric as evidence by a relative afferent pupillary defect in the two patients with decreased vision. In patients affected with Anti-MOG with decreased visual acuity, pattern Visual Evoked Potentials were significantly reduced in amplitude. Other than the initial optic neuritis, one patient experienced no additional neurological effects, while the others experienced scintillating scotomas, recurrent mild paresthesia of both legs, and seizures. The MRIs displayed hyperintense T2 abnormalities in all patients.
Conclusions :
The initial results of this study match existing literature for anti-MOG disease. Optic nerve atrophy is a commonly found ocular sign in patients with anti-MOG. Interestingly, patients were found to have decreased VEP amplitudes but normal inner and outer retinal function. The study recruitment is ongoing.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.