June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
The Save Sight Dry Eye Registry: One year capture of real-world data for dry eye
Author Affiliations & Notes
  • Stephanie L Watson
    Ophthalmology, The University of Sydney Save Sight Institute, Sydney, New South Wales, Australia
  • Maria Paulina Cabrera Aguas
    Ophthalmology, The University of Sydney Save Sight Institute, Sydney, New South Wales, Australia
  • Laura Elizabeth Downie
    Optometry, The University of Melbourne, Melbourne, Victoria, Australia
  • Fiona Stapleton
    Optometry, University of New South Wales, Sydney, New South Wales, Australia
  • David Mingo Botin
    Ophthalmology, Hospital Universitario Ramon y Cajal, Madrid, Madrid, Spain
  • Francisco Arnalich
    Ophthalmology, Hospital Universitario Ramon y Cajal, Madrid, Madrid, Spain
  • Saaeha Rauz
    Ophthalmology, University of Birmingham, Birmingham, Birmingham, United Kingdom
  • Vincent Daien
    Ophthalmology, University Hospital of Montpellier, France
  • Fanny Babeau
    Ophthalmology, University Hospital of Montpellier, France
  • Jennifer P Craig
    Optometry, The University of Auckland Faculty of Medical and Health Sciences, Auckland, Auckland, New Zealand
  • Gerd Geerling
    Ophthalmology, University of Duesseldorf, Germany
  • Footnotes
    Commercial Relationships   Stephanie Watson Novartis, Sequirus, Alcon, Code E (Employment); Maria Cabrera Aguas None; Laura Downie Azura Ophthalmics, CooperVision, Kedalion Therapeutics, Code C (Consultant/Contractor); Fiona Stapleton None; David Mingo Botin None; Francisco Arnalich None; Saaeha Rauz None; Vincent Daien None; Fanny Babeau None; Jennifer Craig None; Gerd Geerling None
  • Footnotes
    Support  Unrestricted educational grant from Novartis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1520 – A0245. doi:
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      Stephanie L Watson, Maria Paulina Cabrera Aguas, Laura Elizabeth Downie, Fiona Stapleton, David Mingo Botin, Francisco Arnalich, Saaeha Rauz, Vincent Daien, Fanny Babeau, Jennifer P Craig, Gerd Geerling; The Save Sight Dry Eye Registry: One year capture of real-world data for dry eye. Invest. Ophthalmol. Vis. Sci. 2022;63(7):1520 – A0245.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : The Save Sight Dry Eye Registry (SSDER) is the first international web-based multinational, interdisciplinary registry able to collect high-quality outcome data from dry eye patients in clinical settings. We report the characteristics of patients with dry eye disease (DED) at their baseline visit from routine clinical practice from 1 November 2020 to 30 November 2021.

Methods : The SSDER collected data from routine clinical practice in Australia, Spain, Germany, and the United Kingdom. Patient demographics, medical history and index visit characteristics including visual acuity, tear break up time (TBUT), ocular surface staining (none, minimal, mild, moderate, severe) and Oxford ocular surface staining score (OSS, 0-15) were recorded in the prospectively designed electronic database. The Ocular Surface Disease Index (OSDI) symptom questionnaire was also completed. Primary outcomes were the baseline demographic data and dry eye diagnosis, and secondary outcomes, logMAR visual acuity, TBUT, and OSS and OSDI scores.

Results : 31 clinicians from 26 sites were registered to use the registry. Data from 122 patients (222 eyes) were curated. Patient age ranged from 18-85 years (mean 58 ± 15 (SD) years) and 98 (87.5%) were female. Mixed DED and evaporative DED comprised the largest groups 107 (48.2%) eyes versus 99 (44.6%) eyes, respectively. The remainder had aqueous deficient DED 14 (6.3%) eyes or neuropathic corneal pain (NCP) 2 (0.9%) eyes. Four (3.5%) patients (8 eyes) wore a contact lens within the month prior to their visit. Most of the patients (90; 177/222 (88%) eyes) had meibomian gland disease.
The median visual acuity and TBUT were 84 (IQR 76-85) logMAR letters and 4 (IQR 2-8) seconds, respectively.
The majority of eyes had minimal or moderate ocular surface staining (none 83(37%); minimal 65(29%); mild 46(21%); moderate 21(9%); severe 7(3%)) that was scored using the OSS as < 3 in 78%(174 eyes), 4-8 in 19%(42), and > 9 in 3%(6). Ninety-six percent of patients completed the OSDI, the median score was 31 (IQR 17-46). The two NCP eyes (one patient) had an OSS of 3 (each eye) and OSDI of 79.

Conclusions : The SSDER allows the efficient capture of dry eye patient data from everyday clinical practice. Meibomian gland disease was present in most patients with dry eye from this real-world setting.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.


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