June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Metabolite and lipid biomarkers associated with intraocular pressure and inner retinal morphology: results from the UK Biobank
Author Affiliations & Notes
  • Louis R Pasquale
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Janey L Wiggs
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Anthony Khawaja
    Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Jae Kang
    Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States
  • Jihye Kim
    Epidemiology, Harvard T.H. Chan School of Public Health, Massachusetts, United States
  • Pirro G Hysi
    Ophthalmology, King's College London, London, London, United Kingdom
  • Tobias Elze
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Jessica Lasky-Su
    Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States
  • Oana Zeleznik
    Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Louis Pasquale Twenty Twenty, Code C (Consultant/Contractor), Skye Bioscience, Code C (Consultant/Contractor), Eyenovia, Code C (Consultant/Contractor); Janey Wiggs None; Anthony Khawaja Abbvie, Code C (Consultant/Contractor), Google, Code C (Consultant/Contractor), Reichert, Code C (Consultant/Contractor), Santen, Code C (Consultant/Contractor); Jae Kang None; Jihye Kim None; Pirro Hysi None; Tobias Elze None; Jessica Lasky-Su None; Oana Zeleznik None
  • Footnotes
    Support  NIH Grant EY015473
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2291. doi:
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      Louis R Pasquale, Janey L Wiggs, Anthony Khawaja, Jae Kang, Jihye Kim, Pirro G Hysi, Tobias Elze, Jessica Lasky-Su, Oana Zeleznik; Metabolite and lipid biomarkers associated with intraocular pressure and inner retinal morphology: results from the UK Biobank. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2291.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the relation between intraocular pressure, macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell inner plexiform layer (mGCIPL) thickness and measured metabolites with emphasis on lipids, lipoproteins and their subclasses, amino acids, and ketone bodies in the UK Biobank.

Methods : We analyzed 167 non-fasting serum metabolites measured by NMR (Nuclear Magnetic Resonance; Nightingale, Finland; version 2020). The sample sizes varied by outcome: 28,780, 10,763, and 10,763 participants, respectively, with data on corneal compensated intraocular pressure (IOPcc), mRNFL, mGCIPL and metabolomics. We used multiple linear regression models adjusting for various covariables (such as age, sex, body mass index, smoking status, diabetes, coronary artery disease, beta blocker use, and statin use) with individual metabolites (probit transformed) as the predictor for each outcome. The reported estimates represent the difference in each outcome variable for each standard deviation increase in the probit-transformed metabolite values. We considered false discovery rates (FDR<0.05) for metabolite classes and number of effective test (NEF<0.05) for individual metabolites as significant after correction for multiple testing.

Results : Overall, associations with mGCIPL were not significant after correction for multiple testing (NEF>0.07). Total branched chain amino acids were associated with lower IOP (-0.17mmHg; 95% confidence interval (CI): -0.12, -022; NEF p-value=4.3E-10) but had null associations with OCT parameters (NEF p-value=1.0). Total concentration of lipoprotein particles was associated with higher IOP (0.11mmHg; 95% CI: 0.05, 0.16; NEF p-value=0.02) and thinner mRNFL (-0.18 microns; 95% CI: -0.27,-0.09; NEF p-value=0.02). Several lipoprotein components (cholesterol, cholesterol esters, phospholipids) carried on LDL and HDL were associated with higher IOP (FDR<0.05) and some were also associated with thinner mRNFL (example: cholesterol esters in small HDL particles: -0.19 microns; 95%CI: -0.28,-0.09; NEF p-value=0.03). Interestingly, cholesterol and cholesterol esters carried on VLDL particles were associated with lower IOP and thicker mRNFL (FDR <0.05 for both).

Conclusions : Higher serum levels of LDL and HDL as well as many of their components were associated with higher IOP and thinner mRNFL in a large population based sample.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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