June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Long-Term Alcohol Consumption and Risk of Exfoliation Glaucoma among US Health Professionals
Author Affiliations & Notes
  • Jae Kang
    Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States
  • Akiko Hanyuda
    Medicine, Keio Gijuku Daigaku Igakubu Daigakuin Igaku Kenkyuka, Shinjuku-ku, Tokyo, Japan
  • Bernard Rosner
    Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States
  • Janey L Wiggs
    Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Louis R Pasquale
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Jae Kang None; Akiko Hanyuda None; Bernard Rosner None; Janey Wiggs Aerpio pharmaceuticals, Code C (Consultant/Contractor), Allergan, Editas, Maze, Regenxbio, Avellino, Code F (Financial Support); Louis Pasquale Twenty Twenty, Skye Bioscience, Eyenovia, Code C (Consultant/Contractor)
  • Footnotes
    Support  UM1 CA186107, UM1 CA167552, UM1 CA176726, R01 EY09611, R01 EY015473.
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2265. doi:
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    • Get Citation

      Jae Kang, Akiko Hanyuda, Bernard Rosner, Janey L Wiggs, Louis R Pasquale; Long-Term Alcohol Consumption and Risk of Exfoliation Glaucoma among US Health Professionals. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2265.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : High alcohol consumption decreases the bioavailability of dietary folate, a possible factor important for exfoliation glaucoma (XFG). We assessed the association between alcohol intake and incidence of XFG in a prospective study.

Methods : We followed 195,408 participants of the Nurses’ Health Study (1980–2018), the Health Professionals Follow-up Study (1986–2018), and the Nurses’ Health Study II (1991–2019) biennially. Eligible subjects at each 2-year risk period were 40+ years old and free of XFG with available data on diet and ophthalmic examinations. We evaluated cumulatively-averaged total alcohol (primary exposure); information for individual alcoholic beverages including beer, wine, and liquor were obtained from validated dietary food frequency questionnaires repeated every 2-4 years. The main outcome of XFG incidence was confirmed by medical records. We used per-eye Cox proportional hazards models, accounting for inter-eye correlations, to estimate multivariable-adjusted relative risks (MVRRs) and 95% confidence intervals (CIs)

Results : During 6,878,075 eye-years of follow-up, 702 eyes with XFG were documented. Greater total alcohol consumption was significantly associated with XFG risk: the MVRR for cumulatively averaged alcohol consumption ≥15+ g/day vs. non-drinking was 1.54 (95% CI, 1.16–2.05; Ptrend=.02). Long- and short-term alcohol intake was significantly associated with XFG risk, with the strongest associations with cumulatively-averaged alcohol intake as of 4 years before diagnosis (MVRR ≥15+ g/day vs. non-drinking=1.62 [95% CI, 1.23–2.14; Ptrend=.003]). Stratifying alcohol consumption by type of beverage revealed a significant trend for liquor. Compared to non-drinkers, consuming 3.6+ drinks per week of beer, total wine or liquor was associated with the following MVRRs for XFG: 1.25 (95% CI, 0.88–1.77; Ptrend=.43), 1.34 (95% CI, 1.03–1.73; Ptrend=.10) and 1.41 (95% CI, 1.11–1.79; Ptrend=.02), respectively. We did not observe interactions by age, latitude, residential tier, intakes of folate or vitamin A (Pinteraction>.40); however, the association between alcohol and XFG was suggestively stronger for those without family history of glaucoma (Pinteraction=.10).

Conclusions : Alcohol consumption was associated with higher risk of XFG, an association that provides more clues regarding the etiology of XFG

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.


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