Abstract
Purpose :
To investigate the correlation between the morphology, autofluorescence and sensitivity of photocoagulated lesions in patients with proliferative diabetic retinopathy (PDR) with good vision.
Methods :
Patients with PDR (n=17) who visited Osaka University Hospital from April 2019 to October 2021 and underwent panretinal photocoagulation more than one year ago (BCVA≧0.8) were included. Maintenance of the circulation of photocoagulation scars was confirmed by optical coherence tomography (OCT) angiography (Angioplex Elite 9000), while autofluorescence of photocoagulated lesions were evaluated using ultra-widefield retinal imaging(Optos: TX-200). The scars were then classified according to levels of autofluorescence—group A for those with no autofluorescence, group B for those with remaining autofluorescence, and group C as control. OCT (Spectralis) was used to evaluate the ellipsoid zone (EZ) lines of the photocoagulated lesions.
Results :
The retinal sensitivities of photocoagulated lesions were 3.3±5.0dB, 15.3±4.4dB and 21.8±2.4dB for groups A (n=35), B (n=37) and C (n=32), respectively, while the percentages of remaining EZ lines were 5.7%, 81.1% and 100%, respectively. There are significant statistical differences (P <0.05) in both the retinal sensitivities of photocoagulated lesions and the percentages of remaining EZ lines.
Conclusions :
The photoreceptors in photocoagulated lesions with autofluorescence retain morphology and some function.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.