June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Incidence, Visual Impairment and Blindness due to Retinitis Pigmentosa in Rural Population in India: 15 Year Follow-up of the Andhra Pradesh Eye Disease Study cohort
Author Affiliations & Notes
  • Rohit C Khanna
    Allen Foster Research Centre for Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye care, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Deepika Parameswarappa
    Srimati Kanuri Santhamma Center for Vitreo - Retinal Diseases, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Srinivas Marmamula
    Allen Foster Research Centre for Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye care, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Asha Latha Mettla
    Allen Foster Research Centre for Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye care, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Pyda Giridhar
    Allen Foster Research Centre for Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye care, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Seema Banerjee
    Allen Foster Research Centre for Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye care, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Konegari Shekhar
    Allen Foster Research Centre for Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye care, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Subhabrata Chakrabarti
    Brien Holden Eye Research Centre, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Subhadra Jalali
    Srimati Kanuri Santhamma Center for Vitreo - Retinal Diseases, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Gullapalli N Rao
    Allen Foster Research Centre for Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye care, L V Prasad Eye Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India
  • Footnotes
    Commercial Relationships   Rohit Khanna None; Deepika Parameswarappa None; Srinivas Marmamula None; Asha Latha Mettla None; Pyda Giridhar None; Seema Banerjee None; Konegari Shekhar None; Subhabrata Chakrabarti None; Subhadra Jalali None; Gullapalli Rao None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2156 – A0184. doi:
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      Rohit C Khanna, Deepika Parameswarappa, Srinivas Marmamula, Asha Latha Mettla, Pyda Giridhar, Seema Banerjee, Konegari Shekhar, Subhabrata Chakrabarti, Subhadra Jalali, Gullapalli N Rao; Incidence, Visual Impairment and Blindness due to Retinitis Pigmentosa in Rural Population in India: 15 Year Follow-up of the Andhra Pradesh Eye Disease Study cohort. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2156 – A0184.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The Andhra Pradesh Eye Disease Study III (APEDS III) represents a 15 year follow up of a cohort of participants who were initially evaluated in APEDS I from 1996-2000. It included the surviving participants from all age groups (n=5395; 83.6%) belonging to three rural areas of APEDS I. The present study was aimed to assess the incidence, visual impairment (VI) and blindness due to Retinitis Pigmentosa (RP) in this rural Southern Indian cohort.

Methods : Following a detailed interview, all the participants underwent a comprehensive eye examination including fundus photography and diagnostic tests. Visual acuity (VA) was measured using a standard logarithm of minimum angle of resolution (logMAR) chart at a distance of three meters. Unaided, presenting, pinhole and best-corrected VA were also recorded. All participants with RP of APEDS I were followed up until APEDS III. Descriptive statistics using mean ± standard deviation with inter-quartile range (IQR) were calculated. Main outcome measures were RP incidence, VI and blindness as per World Health Organization criteria.

Results : At baseline (APEDS I), 7771 participants residing in three rural areas were examined. There were 9 cases of RP with mean age at baseline of 47.33 ± 10.89 years (IQR 39-55). There was a male preponderance (6:3) and the mean best-corrected visual acuity (BCVA) of 18 eyes from nine participants was 1.2 ± 0.72log MAR (IQR 0.7-1.6). Over a mean follow-up duration of 15 years, 5395/7771 (69.4%) were reexamined, which included 7 RP participants from APEDS I. Additionally, 2 new cases of RP were identified that provided an overall incidence of 370/million in 15 years (24.7/million per year). The mean BCVA of 14 eyes of seven patients who were reexamined in APEDS III was 2.17±0.56log MAR (IQR 1.8-2.6) and 5 of these 7 patients developed incident blindness during the follow-up period.

Conclusions : The overall incidence of RP was relatively high in the Southern Indian population and this information would be valuable in planning for future eye care strategies to address and prevent this condition.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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