June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Macular Pigment Optical Density and Its Determinants in a Russian population. The Ural Eye and Medical Study
Author Affiliations & Notes
  • Ellina Iakupova
    Ufa Eye Research Institute, Russian Federation
  • Songhomitra Panda-Jonas
    Ufa Eye Research Institute, Russian Federation
  • Mukharram Bikbov
    Ufa Eye Research Institute, Russian Federation
  • Gyulli Kazakbaeva
    Ufa Eye Research Institute, Russian Federation
  • Jost Jonas
    Ufa Eye Research Institute, Russian Federation
  • Footnotes
    Commercial Relationships   Ellina Iakupova None; Songhomitra Panda-Jonas None; Mukharram Bikbov None; Gyulli Kazakbaeva None; Jost Jonas None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2138 – A0166. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ellina Iakupova, Songhomitra Panda-Jonas, Mukharram Bikbov, Gyulli Kazakbaeva, Jost Jonas; Macular Pigment Optical Density and Its Determinants in a Russian population. The Ural Eye and Medical Study. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2138 – A0166.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To assess the macular pigment optical density (MPOD) and its associations with ocular and systemic parameters and diseases.

Methods : The Ural Eye and Medical Study included 5899 (80.5%) out of 7328 eligible individuals. As part of ophthalmological and systemic examinations, MPOD was measured by reflectometry.

Results : MPOD data were available for 4889 (82.9%) individuals (mean age:57.8±10.1 years;range:40-94). Mean values for MOPD, maximal MOPD, macular pigment (MP) area and MP volume were 0.13±0.04 d.u. (density units), 0.36±0.09 d.u., 60,791±14,826 pixel, and 8,033±2,888 d.u.pixel, respectively. A higher MP density correlated (regression coefficient r:0.63) with older age (standardized regression coefficient beta:0.59;non-standardized regression coefficient B:0.23;95% confidence interval (CI):0.22,0.23;P<0.001), female sex (beta:0.08;B:0.63;95%CI:0.44,0.83;P<0.001), rural region of habitation (beta:0.13;B:1.02;95%CI:0.0.83,1.22;P<0.001), lower body mass index (beta:-0.04;B:-0.03;95%CI:-0.05,0.01;P=0.004), lower prevalence of chronic obstructive pulmonary disorder (beta:-0.03;B:-0.43;95%CI:-0.79,-0.08;P=0.02), higher erythrocyte sedimentation rate (beta:0.03;B:0.01;95%CI:0.002,0.02;P=0.03), lower leukocyte cell count (beta:-0.04;B:-0.10;95%CI:-0.16,-0.03;P=0.003), thinner temporal parafoveal retinal thickness (beta:-0.06;B:-0.01;95%CI:-0.01,-0.003;P<0.001), thinner central corneal thickness (beta:-0.06;B:-0.006;95%CI:-0.009,-0.004;P<0.001), higher prevalence of previous cataract surgery (beta:0.09;B:2.08;95%CI:1.50,2.65;P<0.001) and reticular pseudo drusen (RPD) (beta:0.03;B:0.56;95%CI:0.13,0.98;P=0.01), and lower stage of open-angle glaucoma (beta:-0.03;B:-0.39;95%CI:-0.74,-0.04;P=0. 03). Prevalence (P=0.44;beta:-0.01) and degree (P=0.70;beta:-0.01) of angle-closure glaucoma, prevalence (P=0.31;beta:0.01) of age-related macular degeneration (AMD) without RPD, and prevalence (P=0.95;beta:0.001) of diabetic retinopathy were not significantly associated with the mean MP density in that model.

Conclusions : After adjusting for age, sex, rural region, body mass index, perifoveal retinal thickness, central corneal thickness and previous cataract surgery, a higher MPOD correlated with a higher RPD prevalence and lower stage of open-angle glaucoma, but not with AMD independently of RPD.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×