June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Optical Coherence Tomography Angiography and Humphrey Visual Field in Patients with Obstructive Sleep Apnea
Author Affiliations & Notes
  • Lindsay Williamson
    Southeast Retina Center, PC, Augusta, Georgia, United States
  • Arash Davanian
    Ophthalmology, Augusta University, Augusta, Georgia, United States
    Eye Institute, Vanderbilt University, Nashville, Tennessee, United States
  • Caitlen Taylor
    Southeast Retina Center, PC, Augusta, Georgia, United States
  • Abigail Harrover
    Ophthalmology, Augusta University, Augusta, Georgia, United States
  • Kathryn E Bollinger
    Ophthalmology, Augusta University, Augusta, Georgia, United States
  • Bashir Chaudhary
    The Sleep Institute of Augusta, Augusta, Georgia, United States
  • Varsha Taskar
    Sleep Medicine, Augusta University, Augusta, Georgia, United States
  • Tae Jin Lee
    Ophthalmology, Augusta University, Augusta, Georgia, United States
  • Yuhan Liu
    Biostatistics, Vanderbilt University, Nashville, Tennessee, United States
  • Qingxia Chen
    Eye Institute, Vanderbilt University, Nashville, Tennessee, United States
    Biostatistics, Vanderbilt University, Nashville, Tennessee, United States
  • Dennis M Marcus
    Southeast Retina Center, PC, Augusta, Georgia, United States
    Ophthalmology, Augusta University, Augusta, Georgia, United States
  • Footnotes
    Commercial Relationships   Lindsay Williamson None; Arash Davanian None; Caitlen Taylor None; Abigail Harrover None; Kathryn Bollinger None; Bashir Chaudhary None; Varsha Taskar None; Tae Jin Lee None; Yuhan Liu None; Qingxia Chen None; Dennis Marcus None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2947 – F0100. doi:
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    • Get Citation

      Lindsay Williamson, Arash Davanian, Caitlen Taylor, Abigail Harrover, Kathryn E Bollinger, Bashir Chaudhary, Varsha Taskar, Tae Jin Lee, Yuhan Liu, Qingxia Chen, Dennis M Marcus; Optical Coherence Tomography Angiography and Humphrey Visual Field in Patients with Obstructive Sleep Apnea. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2947 – F0100.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine if obstructive sleep apnea (OSAS) predisposes patients to glaucoma and macular disease due to vascular compromise by evaluating retinal and optic nerve vasculature and function using optical coherence tomography angiography (OCT-A) and Humphrey visual field testing.

Methods : Forty-five patients undergoing polysomnography ordered per standard of care were enrolled and grouped into three categories based on apnea-hypopnea index (AHI) with control patients having AHI <5 episodes/hr. Medical history, visual acuity testing, 24-2 Humphrey visual field (HVF), intra-ocular pressure measurement, OCT-A studies of the macular and peripapillary retina were obtained. Correlations between polysomnography parameters and imaging data were evaluated.

Results : OCT-A radial peripapillary capillary (RPC) vascular density (VD) demonstrated no relationship to AHI (95% CI (-0.026,0.038)) or severity of OSAS (95% CI: (-0.772, 3.648) for moderate OSAS compared to mild/normal and (-1.295, 3.1421) for severe comparing to mild/normal). OCT-A superficial parafoveal VD (95% CI: (-0.068,0.011), deep parafoveal VD (95% CI: (-0.080,0.009)), and FAZ (95% CI: (-0.001, 0.001)) showed no statistically significant relationship to AHI or OSAS severity after controlling for confounders. OCT retinal nerve fiber layer (RNFL) thickness increased with AHI (p=0.014), but there was no statistically significant correlation with OSAS severity with RNFL thickness (95% CI: (-12.543, 6.792) for moderate comparing to normal and (-2.883, 16.551) for severe comparing to normal). 24-2 HVF parameters were unaffected by OSAS (95% CI: Mean deviation (-0.21,0.29), Pattern standard deviation: (-0.351,0.121), Visual field index: (-0.166, 0.329)). OCT choroidal thickness showed a statistically significant decrease when OSAS was grouped by severity (p=0.0092), but did not correlate with AHI (p=0.129, 95% CI: (-1.210, 0.095))

Conclusions : The severity of OSAS did not show a statistically significant effect on parameters associated with glaucoma or macular vascular disease. Larger cohorts may be required to determine the physiologic consequences of OSAS on the macular and optic nerve vasculature, structure, and function.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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