Abstract
Purpose :
To investigate the association between macular perfusion density and functional or anatomical impairment in various stages of glaucoma.
Methods :
We retrospectively examined 147 medically treated primary open-angle glaucoma eyes. All the patients underwent static perimetry using the Humphrey Field Analyzer program Central 10-2, spectral-domain optical coherence tomography (OCT), and 6 × 6-mm optical coherence tomography angiography (OCT-A) centered on the fovea.
Results :
The mean age was 64.0 ± 10.9 years (males: 62, females: 85). The mean intraocular pressure was 13.1 ± 2.1 mmHg. Macular perfusion density was positively correlated with sensitivity corresponding to central visual field and macular thickness in all 8 sectors (all P < 0.05; Pearson correlation coefficient). In addition, there was a positive correlation between the averaged macular perfusion density and the averaged thickness of the circumpapillary retinal nerve fiber layer (cpRNFL), as well as between the macular ganglion cell layer and the inner plexiform layer (mGCIPL) (P = 0.001 and P < 0.0001, respectively; Pearson correlation coefficient).
Conclusions :
Macular perfusion density by OCT-A is highly correlated with both functional and structural changes in glaucoma, and thus its assessment might be useful for monitoring glaucoma.
This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.