June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
OCT ANGIOGRAPHY INDICES AND CHOROIDAL VASCULARITY INDEX IN HEREDITARY TRANSTHYRETIN AMYLOIDOSIS
Author Affiliations & Notes
  • Flavia Chiosi
    Ophthalmology, AORN Ospedali dei Colli, Napoli, Campania, Italy
  • Gianluigi Manzi
    Ophthalmology, AORN Ospedali dei Colli, Napoli, Campania, Italy
  • CIRO COSTAGLIOLA
    Ophthalmology, Universita degli Studi di Napoli Federico II, Napoli, Campania, Italy
  • OTELLO GALLO
    Ophthalmology, AORN Ospedali dei Colli, Napoli, Campania, Italy
  • Erica Paolillo
    Ophthalmology, AORN Ospedali dei Colli, Napoli, Campania, Italy
  • GIUSEPPE LIMONGELLI
    Inherited and Rare Cardiovascular Disease, Universita degli Studi della Campania Luigi Vanvitelli, NAPOLI, Campania, Italy
  • MARTINA CAIAZZA
    Inherited and Rare Cardiovascular Disease, Universita degli Studi della Campania Luigi Vanvitelli, NAPOLI, Campania, Italy
  • GIUSEPPE PALMIERO
    Cardiology, Ospedale Monaldi, Napoli, Campania, Italy
  • Michele Rinaldi
    Ophthalmology, Universita degli Studi della Campania Luigi Vanvitelli, Napoli, Campania, Italy
  • Footnotes
    Commercial Relationships   Flavia Chiosi None; Gianluigi Manzi None; CIRO COSTAGLIOLA None; OTELLO GALLO None; Erica Paolillo None; GIUSEPPE LIMONGELLI None; MARTINA CAIAZZA None; GIUSEPPE PALMIERO None; Michele Rinaldi None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2921 – F0074. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Flavia Chiosi, Gianluigi Manzi, CIRO COSTAGLIOLA, OTELLO GALLO, Erica Paolillo, GIUSEPPE LIMONGELLI, MARTINA CAIAZZA, GIUSEPPE PALMIERO, Michele Rinaldi; OCT ANGIOGRAPHY INDICES AND CHOROIDAL VASCULARITY INDEX IN HEREDITARY TRANSTHYRETIN AMYLOIDOSIS. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2921 – F0074.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Retinal angiopathy is a known ocular manifestation of hereditary transthyretin amyloidosis (ATTR). We performed a retrospective, observational clinical study to determine whether vessel density (VD) indices as measured by optical coherence tomography angiography (OCTA) and choroidal vascularity index (CVI) provided insights into retinal and choroidal vascular changes in patients affected by ATTR.

Methods : Twenty-six patients with genetic diagnosis of wild-type ATTR were enrolled to undergo structural optical coherence tomography (OCT) and OCTA. An age-gender-matched control group of twenty-four healthy subjects was selected for statistical comparisons. Swept-source OCT and OCT angiography data from TOPCON DRI OCT Triton were exported using Topcon IMAGENET 6.0 software, and 3D datasets were analysed to determine retinal, choroidal thickness and VD. Images were binarized using the ImageJ software, and total choroid area (TCA), luminal area (LA) and stromal area (SA) were acquired to measure the CVI. Statistical analysis was conducted using MedCalc version 11.5.1 (Medcalc software, Mariakerke, Belgium).

Results : Mean VD was significantly reduced in the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) in all five Early Treatment Diabetic Retinopathy Study (ETDRS) sectors in the ATTR group compared to controls (P =. 006)
Retinal thickness did not statistically differ between the two groups, while a significantly reduced chororidal thickness was recorded in ATTR patients (P = .008).
The mean CVI was lower in the ATTR group compared to controls (P = .006).

Conclusions : VD resulted reduced at the level of SCP, DCP and CC in ATTR patients, along with choroidal thickness and CVI compared to healthy control.
OCT-A indices and CVI may serve as a noninvasive biomarker to quantitatively evaluate retinal and choroidal vascular involvement in ATTR patients and the possible correlation with systemic parameters.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×