June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Age-related Changes in Dynamic Iris Behavior Assessed Using a Closed-Loop Iris Control System
Author Affiliations & Notes
  • Galo Apolo
    Roski Eye Institute, Department of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Naim Lazkani
    Roski Eye Institute, Department of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Sarah Zhou
    University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Abe Song
    Roski Eye Institute, Department of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Anmol Pardeshi
    Roski Eye Institute, Department of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Robert N Weinreb
    Hamilton Glaucoma Center, Shiley Eye Institute and Viterbi Family Department of Ophthalmology, University of California, San Diego, San Diego, California, United States
  • Benjamin Xu
    Roski Eye Institute, Department of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Galo Apolo None; Naim Lazkani None; Sarah Zhou None; Abe Song None; Anmol Pardeshi None; Robert Weinreb None; Benjamin Xu None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2730 – A0094. doi:
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      Galo Apolo, Naim Lazkani, Sarah Zhou, Abe Song, Anmol Pardeshi, Robert N Weinreb, Benjamin Xu; Age-related Changes in Dynamic Iris Behavior Assessed Using a Closed-Loop Iris Control System. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2730 – A0094.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To develop and test a closed-loop system for modulating iris activity and assessing the role of dynamic iris behavior in primary angle closure disease (PACD).

Methods : Participants aged 18 years or older were recruited from the University of Southern California Roski Eye Institute. Three consecutive videos of one eye per participant were recorded using the ANTERION OCT system (Heidelberg Engineering, Heidelberg, Germany). During recording, custom software was used to control a light-emitting diode (LED) and modulate ambient lighting to hold the iris in a dilated, constricted, or mid-dilated position. Dynamic iris behavior in the form of peak constriction velocity (PCV) and mid-dilated iris activity (MDIA) were measured in real-time. Linear regression analysis was performed to assess the relationship between participant age and PCV and MDIA.

Results : A total of 58 participants were recruited, with 40 (69.0%) being eligible for analysis based on patterns of iris behavior. Mean participant age was 50.0 (SD = 18.7) years. The system maintained a mid-dilated position for 69.0% of the participants with a mean difference of 0.071 (SD = 0.13) mm between the calculated and observed mean mid-dilated pupillary diameters. There was a negative linear correlation between PCV and age (slope= -0.02; p < 0.01) and MDIA and age (slope= -0.003 ; p < 0.01).

Conclusions : A novel closed-loop iris control system can modulate dynamic iris behavior and hold the pupil in a stable mid-dilated state. Dynamic iris behavior during pupillary constriction and in the mid-dilated state decrease with age. This system may be applied in the future to study dynamic disease processes involving the iris, including acute primary angle closure (APAC).

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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