June 2022
Volume 63, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2022
Risk factors for progression of intermediate age-related macular degeneration: A systematic review and meta-analysis
Author Affiliations & Notes
  • Andrew J Lotery
    University of Southampton Faculty of Medicine, Southampton, Southampton, United Kingdom
  • Ahmed M Hagag
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Rebecca Kaye
    University of Southampton Faculty of Medicine, Southampton, Southampton, United Kingdom
  • Sophie Riedl
    Medizinische Universitat Wien, Wien, Wien, Austria
  • Vy Hoang
    University of Southampton Faculty of Medicine, Southampton, Southampton, United Kingdom
  • Philipp Anders
    Institute of Molecular and Clinical Ophthalmology Basel, Basel, Basel-Stadt, Switzerland
    Department of Ophthalmology, University of Basel, Universitat Basel, Basel, Basel-Stadt, CH, academic, Basel, Switzerland
  • Christian Appenzeller-Herzog
    University Medical Library, University of Basel, Universitat Basel, Basel, Basel-Stadt, CH, academic, Switzerland
  • Ursula Schmidt-Erfurth
    Medizinische Universitat Wien, Wien, Wien, Austria
  • Hendrik P Scholl
    Institute of Molecular and Clinical Ophthalmology Basel, Basel, Basel-Stadt, Switzerland
    Department of Ophthalmology, University of Basel, Universitat Basel, Basel, Basel-Stadt, CH, academic, Basel, Switzerland
  • Toby Prevost
    King's College London, London, London, United Kingdom
  • Lars Fritsche
    University of Michigan, Ann Arbor, Michigan, United States
  • Daniel Rueckert
    Imperial College London, London, London, United Kingdom
  • Sobha Sivaprasad
    Moorfields Eye Hospital NHS Foundation Trust, London, London, United Kingdom
  • Ghislaine Traber
    Institute of Molecular and Clinical Ophthalmology Basel, Basel, Basel-Stadt, Switzerland
  • Beth Stuart
    University of Southampton Faculty of Medicine, Southampton, Southampton, United Kingdom
  • Footnotes
    Commercial Relationships   Andrew Lotery Novartis, Allergan, Apellis, Code C (Consultant/Contractor), Gyroscope Therapeutics, Code I (Personal Financial Interest); Ahmed Hagag None; Rebecca Kaye None; Sophie Riedl None; Vy Hoang None; Philipp Anders None; Christian Appenzeller-Herzog None; Ursula Schmidt-Erfurth None; Hendrik Scholl None; Toby Prevost None; Lars Fritsche None; Daniel Rueckert None; Sobha Sivaprasad None; Ghislaine Traber None; Beth Stuart None
  • Footnotes
    Support  Wellcome Trust grant [210572/Z/18/Z]
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2530 – A0099. doi:
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      Andrew J Lotery, Ahmed M Hagag, Rebecca Kaye, Sophie Riedl, Vy Hoang, Philipp Anders, Christian Appenzeller-Herzog, Ursula Schmidt-Erfurth, Hendrik P Scholl, Toby Prevost, Lars Fritsche, Daniel Rueckert, Sobha Sivaprasad, Ghislaine Traber, Beth Stuart; Risk factors for progression of intermediate age-related macular degeneration: A systematic review and meta-analysis. Invest. Ophthalmol. Vis. Sci. 2022;63(7):2530 – A0099.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To perform a comprehensive review of literature and meta-analysis of risk factors that accelerate progression of intermediate age-related macular degeneration (AMD) to late AMD.

Methods : The full protocol was registered on PROSPERO (CRD42021266710).
The search strategies were developed by an information specialist (C.A.-H.). The electronic databases Embase via Elsevier and Medline via Ovid were searched using text word synonyms and database-specific subject headings for AMD and disease progression (last search November 10, 2020). Records published before 1991 were excluded. No language restrictions were applied. The titles and abstracts of references were screened against eligibility criteria including: only studies with a defined grading system; a clear end point of advanced AMD; yearly follow up; in English and fellow eye AMD status known. Selected references were retrieved in full-text and independently assessed for eligibility by two reviewers. Any disagreements over eligibility were solved by discussion with other team members.
A data extraction sheet was constructed based on the modified checklist for critical appraisal and data extraction for systematic reviews of prediction modelling studies (CHARMS-PF). The risk of bias in each of the included studies was assessed using the quality in prognostic factor studies (QUIPS) tool. Data extraction and risk of bias assessment for each article was performed by two reviewers independently.

Results : Our electronic searches identified 3229 unique records. After initial title/abstract screening, 3130 records were deemed ineligible, and 99 papers were selected for the full-text screening. Eight articles met the inclusion criteria and will proceed to the data extraction and risk of bias assessment stages.

Conclusions : Despite extensive studies assessing progression of early or intermediate AMD to late AMD only 0.3 % met our requirements for inclusion in a systematic review. This reflects the heterogeneity of the assessed studies and suggests further consensus is needed on AMD classification systems and acceptable follow up times for cohort studies to ensure they can be included in future meta-analyses.

This abstract was presented at the 2022 ARVO Annual Meeting, held in Denver, CO, May 1-4, 2022, and virtually.

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